Careers

Careers

At Dicerna, we foster a culture of innovation through collaboration.

View our list of career opportunities.

 

We are dedicated to benefiting patients by advancing science and developing creative solutions to challenging therapeutic problems. Our core values of dedication, innovation, communication, excellence, respect, needs based and accountability drive us personally and as a team, and these are critical factors in the long-term success of our company.

We encourage open dialogue to identify and act upon novel ideas to meet the urgent needs of patients.

As innovators in the emerging area of RNAi, we seek forward-thinking talent to join our growing team, advance our robust pipeline of therapies, and provide ground-breaking medicines to those that depend on us.

Our office location in Cambridge underscores our commitment to being an employer of choice in the Massachusetts life sciences sector, and to being in close proximity to world-class research, academic and healthcare institutions as well as other life sciences leaders. We play an active role in the biotechnology community and in the Alewife business community as the area undergoes a revitalization to become a mini life sciences and technology hub. Our office is close to the MBTA subway and buses, the 120-acre Alewife Reservation, as well as many restaurants and services.

 

Dicerna is proud to be an Equal Opportunity Employer.

 

Career Opportunities

  • Research Associate – Oligonucleotide Synthesis

    Posted November 2, 2018

     

    Dicerna Pharmaceuticals is seeking highly motivated scientists to join its oligonucleotide/medicinal chemistry team in Cambridge, Massachusetts. The candidates will be responsible for the synthesis, deprotection, and purification of oligonucleotides, and the analysis and characterization of oligonucleotides. This position will support therapeutic programs in multiple disease areas and will contribute to the development of novel nucleic acid conjugate platforms. Prior experience in oligonucleotide synthesis and characterization is desired but not required.

    Key Responsibilities:

    • Synthesis of oligonucleotides, deprotection, purification, annealing and lyophilization of oligonucleotides to support all disease programs
    • Analytical characterization of the synthesized oligonucleotides for purity determination and impurity profiling
    • Support new chemistry discovery for the development of novel oligonucleotide conjugate platforms
    • Operate, maintain, and troubleshoot lab instruments such as oligonucleotide synthesizers, purification systems, HPLC and LC-MS
    • Conduct laboratory work in safe, efficient manner that ensures a safe working environment for colleagues
    • Ability to complete assignments and meet deadlines and time schedules
    • Keep accurate record of the experiments and summarize the results in written reports
    • Possess excellent written and verbal communication skills
    • Demonstrate an ability to work as part of a team and possess an excellent work ethic
    • Ability to be successful in a fast-paced, intense work environment

    Qualifications:

    • PhD in Chemistry or related field with 1-2 years of industrial experience, or MS with at least 3 years of industrial experience, or BS with 5 Years
    • Strong knowledge of nucleic acids chemistry, oligonucleotide synthesis, deprotection and purification techniques
    • Experience with oligonucleotide synthesizers preferred
    • Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation

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  • Senior Medical Writer

    Posted November 28, 2018

     

    The medical writer will be a key member of the Project Team and will work closely with Research, Clinical Operations and Regulatory Affairs to manage all aspects of document preparation for clinical and regulatory documents according to company guidelines and international governmental regulations.  S/he will provide strategic direction to cross-functional teams to ensure that key messages are consistently aligned with reporting requirements and company objectives.

     

    Key Responsibilities: 

    • Plan, prepare, write, edit, format, and finalize non-clinical, clinical, CMC and regulatory documents. Documents will include, but are not limited to: IND, CTA, non-clinical summaries, clinical protocols, clinical study reports, Investigator brochures, updates to regulatory submissions, annual reports/development safety update reports (DSURs), IMPDs etc.
    • Assist in developing strategy for organizing and preparing documents for regulatory health authority submissions.
    • Coordinate the internal review of documents.
    • Develop, maintain, and drive document finalization timelines.
    • Ensure final document adheres to standard operating procedures (SOP), good clinical practice (GCP), and the International Council on Harmonisation (ICH).
    • Perform quality control review of medical writing documents
    • Assist in the development of templates, style guidelines, and SOPs for clinical documentation

    Qualifications:

    • Minimum requirement of a bachelor’s degree with 8+ years of medical writing experience in a pharmaceutical/biotechnology or CRO environment
    • Ability to interpret and present clinical and non-clinical data objectively in a clear, concise format.
    • Outstanding written and oral communication skills
    • Proficiency in teamwork, organization, and project management
    • Proficiency in MS Office; experience using electronic document management system

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  • Research Associate/Associate Scientist, RNAi Pharmacology

    Posted December 6, 2018

     

    Dicerna is a rapidly growing biopharmaceutical company focused on the discovery and development of innovative therapeutics for rare diseases, chronic liver diseases, cardiovascular disease, and infectious diseases.  The Company is using its proprietary GalXC™ RNAi technology platform to build a broad pipeline in these therapeutic areas.  Dicerna offers a unique and exceptional culture that thrives on energy, sharing of ideas and overall excellence.  We believe in career development and enhancing the work environment with industry-leading perks (daily catered lunches, fun corporate outings, community volunteering opportunities).  We offer competitive salaries and excellent benefits.

     

    Key Responsibilities

    • Rodent dosing, sampling and necropsy; planning and performing of all technical aspects of in vivo experiments; contributing to experimental design and strategy
    • Cross-functional collaboration to help enable efficient operation of our on-site animal care facility (ACF)
    • Performing laboratory assays according to SOPs, troubleshooting as needed; assay development. Generating data using both standard and novel molecular technologies
    • Maintaining careful laboratory notebooks and generating high quality study reports
    • Contributing to a team tasked with evaluating novel experimental medicines in preclinical models of disease, and advancing our technology to enable development of the next generation of innovative RNA-based therapeutics

    Qualifications

    • BS or MS in Biology, Pharmacology, Biochemistry, Pharmaceutical Sciences or equivalent
    • 1+ years (Research Associate) or 5+ years (Associate Scientist) of experience in a relevant industrial or academic setting
    • Experience in rodent pharmacology including dosing, tissue collection and study management and study documentation
    • Experience in standard laboratory methodologies; aseptic technique; working knowledge of molecular biology.  Examples include qPCR, immunohistochemistry, ELISA/Western, FACS
    • Experience in data analysis methods, including scientific software
    • Commitment to careful and thorough technical documentation, including electronic laboratory notebooks and study reports
    • Ability to interact effectively on multidisciplinary teams and participate in our exciting, dynamic company culture; ability to work independently
    • Ability to multitask and prioritize

     

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  • Clinical Trial Associate

    Posted December 14, 2018

     

    We are seeking a highly organized and detail oriented Clinical Trial Associate (CTA) to assist with the execution of clinical trials.

     Key Responsibilities

    • Support clinical development team in the overall management of studies, including planning, execution and closeout of outsourced clinical trials.
    • Assist Clinical Project Manager in site management activities: could include review of monitoring report, tracking of site visits, and communication with monitors and sites,.
    • Work closely with clinical project managers to assist with preparation of all external and internal documentation for assigned trials to ensure it’s completed in accordance with GCP regulatory requirements and consistent with the study protocol.
    • Assist in the creation of and distribution of study materials and communications to KOLs, CROs and other external vendors.
    • Organize and prepare study files related to study tracking and reporting and submit them to the Trial Master File within established guidelines, maintain up-to-date documentation for all study sites globally.
    • Assist the project team with planning, preparation and possible on-site support of investigator’s meetings.
    • Support invoice and budget activities

    Qualifications

    • Bachelor’s degree with a life science or healthcare focus
    • A minimum of 3+ years of supporting clinical studies at a CRO or biopharma company
    • Strong interpersonal, organizational and multi-tasking skills; attention to detail
    • Working knowledge of ICH GCP regulations and clinical protocols
    • Sound analytical and problem- solving skills; ability to act with a consistent sense of urgency

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  • Quality Control (QC) Manager (Boulder, CO Location)

    Posted December 20, 2018

     

    The QC Manager will manage and oversee QC testing and reporting performed at Contracted manufacturing and testing companies.  This includes testing and ongoing stability of starting materials, Drug Substance and Drug Product.  Assist in all aspects of quality control in respect to clinical trial materials and commercial products as required. This position provides QC support to the Development, Operations, QA/QC, and Regulatory Affairs departments.  Analytical experience with oligonucleotides is preferred.

     Key Responsibilities

    • Demonstrate technical proficiency in analytical methodology and ensure quality control activities are carried out according to and with adherence to regulatory and internal requirements, cGMP and ICH compliance.
    • Create, revise, review and approve protocols, supporting analytical data, and reports associated with method validation, testing, and release of GMP starting materials, intermediates, APIs, Drug Products.
    • Manage and oversee Dicerna’s Stability Program.
    • Generate and maintain a product status tracking system.
    • Serve as QC lead on analytical project teams and product operational teams.
    • Conduct or support investigations regarding out-of-trend (OOT)/out-of-specification (OOS) results.
    • Write/revise SOPs, technical protocols and reports.
    • Work with the quality control management team to continuously improve the quality, compliance and efficiency of QC operations.
    • Effectively communicate internal issues related to performance, processes, and procedures.
    • Be a self-starting problem solver who drives results through high compliance and a positive work style.

    Qualifications

    To perform this job successfully, an individual must have the following educational degrees and/or experience:

    • BS/BA in science related field or equivalent experience with 6+ years of related Quality Control experience.
    • 4-5+ years of QC supervisory or management experience in biotech or pharmaceutical position, particularly in a GMP environment.
    • Ability to perform analytical methods and interpret data including, but not limited to:  Chromatography, Mass Spec, FTIR, metals testing, vapor pressure and freezing point osmolality, purity by IP-RP-UPLC with UV, endotoxin, BSFS, sterility, and bioburden.
    • Knowledge of FDA cGMP regulations, ICH and FDA Guidances for Industry, Compendial requirements, other-country regulations and standards.
    • Expertise in data analysis including reviewing and reporting data.
    • Strong problem solving/analytical skills.
    • The ability to work independently with minimal supervision, interact with staff (at all levels) in a fast-paced environment, sometimes under pressure, remaining flexible, proactive, resourceful and efficient, with a high level of professionalism.
    • Excellent written and verbal communication skills, strong negotiation and decision-making skills, and attention to detail are equally important.
    • Strong organizational skills, with the ability to handle multiple tasks in a fast-paced environment.

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  • Research Associate 2019A, RNAi Discovery

    Posted January 3, 2019

     

    Dicerna Pharmaceuticals is looking for a BS/MS scientist to help in its drug discovery efforts.  This is a hands-on research position that requires strong expertise in in vivo (mouse) and in vitro methodologies.  This is a full-time position. Dicerna offers an exciting work environment and strong team culture. Our company has a competitive benefits package and bonus incentive program.

     Key Responsibilities

    • siRNA drug candidate screening, hit identification, and lead optimization
    • In vivo drug candidate testing (e.g. mouse dosing; sample analysis)
    • Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; PCR

    Qualifications

    • BS/MS in a relevant field and 0-5 year’s postgraduate experience, preferably in drug discovery and in an industry setting (junior or experienced candidates considered, with level and compensation commensurate with experience)
    • Experience with in vivo methodologies is essential (e.g. mouse handling; dosing – subcutaneous, intraventricular; sample analysis; histology)
    • Experience with in vivo neural techniques is preferred (e.g. stereotaxic surgery; intrathecal injections)
    • Expertise in cellular and molecular biology is preferred (e.g., mammalian cell culture; cell-based assays; quantitative real-time PCR)
    • Experience with RNAi is preferred; experience with in vitro screening is preferred
    • The individual should have strong oral and written communication skills and a demonstrated ability to contribute effectively to group projects in a team-oriented environment.
    • Ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected

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  • Scientist 2019A, RNAi Discovery

    Posted January 3, 2019

     

    We are looking for a PhD scientist to help in our drug discovery efforts.  This is a hands-on research position that requires strong expertise in in vivo (mouse) and in vitro methodologies. This is a full-time position. Dicerna offers an exciting work environment and strong team culture. Our company has a competitive benefits package and bonus incentive program

    Key Responsibilities

    • siRNA drug candidate screening, hit identification, and lead optimization
    • In vivo drug candidate testing (e.g. mouse dosing; sample analysis)
    • Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; PCR

    Qualifications

    • PhD in a relevant field and 0-5 year’s postgraduate experience, preferably in drug discovery and in an industry setting (junior or experienced candidates considered, with level and compensation commensurate with experience)
    • Experience with in vivo methodologies is essential (e.g. mouse handling; dosing – subcutaneous, intraventricular; sample analysis; histology)
    • Experience with in vivo neural techniques is preferred (e.g. stereotaxic surgery; intrathecal injections)
    • Expertise in cellular and molecular biology is preferred (e.g., mammalian cell culture; cell-based assays; quantitative real-time PCR)
    • Experience with RNAi is preferred; experience with in vitro screening is preferred
    • The individual should have strong oral and written communication skills and a demonstrated ability to contribute effectively to group projects in a team-oriented environment
    • Ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected

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  • Manager- Chemistry, Manufacturing, & Controls (CMC)

    Posted January 9, 2019

     

    We are seeking a highly experienced and dynamic professional to support all chemistry, manufacturing and controls (CMC) regulatory and manufacturing requirements for Dicerna’s investigational products pipeline.

    In this role, you will be responsible for preparing CMC regulatory submissions and providing strategic input and risk assessments throughout the product lifecycle. Additionally, you will provide CMC guidance and support to internal groups such as quality, manufacturing, supply chain and regulatory affairs, as well as to outside groups, such as contract manufacturing organizations to ensure that products are manufactured in compliance with all applicable regulations.

    Key Responsibilities

    • Compile, review and approve high-quality CMC modules for development and marketing registration applications, amendments, and supplements for submission, ensuring complete CMC content that meets current regional requirements and FDA/EU/World Health Authority requirements.
    • Support the review of CMC content for accuracy, including data verification, clarity, consistency, and conformance to writing conventions, and present findings to management.
    • Oversee functions within CMC, including but not limited to defining specifications, trending and analyzing batch data, maintain internal and external CMC documents, and supporting and defining aspects of distribution and release management.
    • Work within the CMC function to help generate manufacturing summary reports to inform product and process development and to help identify and monitor product yields and/or quality.
    • Develop and distribute periodic reports on performance, issues, risks, and schedules of key activities, events, or milestones.
    • Serve as a CMC project contact with external and internal clients, as needed.
    • Identify project issues and contribute to the development of alternative CMC Regulatory strategies.

    Qualifications

    • Advanced degree in the Life Sciences or related field preferred.
    • Minimum of 10 years of relevant experience in pharmaceutical or biotechnology industry
    • Demonstrated experience with oligonucleotide therapeutics and minimum 3-5 years direct involvement with CMC operation efforts.
    • Excellent written and verbal communication skills.
    • Strong analytical skills and problem-solving skills
    • Adept at managing competing priorities and timelines in a fast-paced, rapid-growth environment
    • Ability to work collaboratively with cross-functional teams, contractors and external regulatory agencies to drive results and meet company objectives
    • Ability to function independently as well as in a team-based environment
    • Minimal travel required

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  • Research Associate/Senior Research Associate – Neuro Discovery

    Posted January 9, 2019

     

    Dicerna Pharmaceuticals is seeking a highly motivated Senior Research Associate to join their newly initiated Neuro Discovery group. This individual will be a key player in investigating the mechanism of action and pharmacological properties of Dicerna’s RNAi therapeutics in the central and peripheral nervous system.

    Key Responsibilities:

    • Rodent dosing, sampling, and necropsy; planning and performing all technical aspects of in vivo experiments; contributing to experimental design and strategy
    • Performing cellular and molecular biology assays according to SOPs and troubleshooting or developing assays as needed
    • Maintaining careful laboratory notebooks, generating high quality study reports, and presenting working progress to team members in group meeting
    • Reviewing literature and providing insights to research directions, while predominantly making hands-on contributions to research

    Qualifications:

    • BS or MS in Biology, Pharmacology, Pharmaceutical Sciences or equivalent
    • 2+ years of experience in a relevant industrial or academic setting, with emphasis on the study of neurology or neurodegenerative disorders
    • Experience in rodent in vivo studies, including dosing, tissue collection, study management, and study documentation.
    • Experience in standard laboratory methodologies; aseptic technique; working knowledge of molecular biology. Key assays for this role include CNS tissue sectioning, RT-qPCR, immunohistochemistry, ELISA, and Western blot
    • Experience in data analysis methods, including scientific software
    • Commitment to careful and thorough technical documentation, including electronic laboratory notebooks and study reports
    • Ability to interact effectively on multidisciplinary teams and participate in our exciting, dynamic company culture; ability to work independently

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  • Supply Chain Sr. Specialist/Lead

    Posted January 11, 2019

     

    We are seeking a highly motivated, organized, and detail-oriented individual with experience in a GxP environment to be responsible for logistics (international and domestic) and to assist with other supply chain functions including materials planning and procurement activities in a growing company. Must have experience with international shipping and customs requirements.

    Key Responsibilities:

    • Well versed in requirements for international shipments associated with IMP and laboratory samples
    • Initiate, monitor, and complete shipments associated with raw materials, drug substance, drug product, and finished goods
    • Ensure prompt shipment and communication to key internal stakeholders
    • Improve tracking system for shipments
    • Management of inventory (Raw materials, Drug substance, Drug Product)
    • Shipping validation activities
    • Import/export expertise
    • 3PL management
    • Oversight of implementation of inventory system
    • Shipping qualifications

    Qualifications:

    • BS in Business or related subject required
    • 3+ years working in supply chain function
    • Excellent knowledge of logistics procedures
    • Experience in Biopharmaceutical & clinical planning
    • Experience in materials management
    • Detailed knowledge of import/export requirements for IMP and raw materials
    • CPIM/CLTD/CSCP certification a plus

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  • Senior Manager, Quality Validation

    Posted January 29, 2019

     

    The Sr. Manager of Validation will:

    • Provide Quality oversight and leadership for validation activities related to Dicerna products produced at 3rd party CMOs / CTLs
    • Manage and coordinate process monitoring and continuous improvement initiatives as related to validation master plans per GMP requirements, as required.
    • Participate in providing quality input for protocol generation, execution, and final package preparation for process, equipment, facility and method validation activities. Review and approve equipment/facilities/utilities requirements, qualification protocols and summary reports, as well as requirements traceability matrices for compliance to quality system requirements.
    • Development and implementation of SOPs/Guideline documents with systemic procedural improvements related to validation activities.
    • Interact with third party manufacturers remotely and/or on-site.
    • Review and approve change controls related to the implementation of process changes, method improvements and equipment upgrades
    • Identify roadblocks and barriers; develop resolutions and know when to communicate them; provide clear communication to team members to meet project expectations; analyze data; evaluate results; form conclusions; recommend equipment and/or process improvements.
    • Provide Quality oversight and leadership for Computer System validation activities
    • Manage QA review and approvals of investigations, qualifications, validations protocols and reports
    • Lead and represent QA Validation in multi-departmental meetings & project teams owned by QA Validation.
    • Support site QA organizations during regulatory inspections
    • Support continuous improvement activities
    • Present key issues related to product quality to Quality Management
    • Be a self-starting problem solver who drives results through high compliance and a positive work style.

    Key Responsibilities and Major Duties

    The Sr. Quality Assurance Manager / Associate Director’s main responsibility is to provide Quality oversight of facilities, equipment, processes, cleaning, and method validations in a cGMP environment performed for Dicerna at Contract Manufacturing Organizations/Contract Testing Labs. Internal Dicerna validation systems may include computer systems validation oversight. The position will review and approve validation documentation, batch records and change controls, as well as provide input for GMP validation activities against regulatory requirements. Additional responsibilities may include conducting internal/external audits and training. This position provides quality recommendations and guidance to project teams and manages other compliance duties as assigned.

    Qualifications

    To perform this job successfully, an individual must have the following educational degrees and/or experience:

    • Bachelor of Arts/Sciences (BA/BS) degree, or higher, in a technical discipline (physical, engineering, chemical or biological sciences) is required.
    • 7+ years’ experience in a cGMP regulated manufacturing environment, with exhibited knowledge or proficiency in regulations related to process validation, process sciences and change control.
    • Organizational and management skills to communicate to multi-discipline project groups.
    • Ability to speak, present data, and defend approaches in front of audiences and inspectors.
    • Ability to comprehend technical information related to equipment, processes, and regulatory expectations.
    • Experience and participation in regulatory inspections presenting departmental functions in audits or regulatory inspections.
    • Knowledge of GLP, GMP, GCP, Part 11 regulations, FDA Guidance’s for Industry, EU regulations, and other standards.
    • Knowledge of regulatory requirements for computer system validation.
    • The ability to think strategically and maintain an attention to detail.
    • The ability to interpret and apply these regulations and requirements to daily work.
    • Strong problem solving/analytical skills.
    • Knowledge of Microsoft Office® applications and spreadsheet programs such as Excel, Word, Power Point, and Microsoft Project.
    • The ability to work independently with minimal supervision, interact with staff (at all levels) in a fast-paced environment, sometimes under pressure, remaining flexible, proactive, resourceful and efficient, with a high level of professionalism.
    • Excellent written and verbal communication skills, strong negotiation and decision-making skills, and attention to detail are equally important.
    • The ability to comprehend regulations and guidance documents and apply critical thinking skills to evaluate requirements and effectively communicate written and oral findings.
    • Strong organizational skills, with the ability to handle multiple tasks

    KNOWLEDGE AND SKILL REQUIREMENTS

    • Leadership
    • People Skills
    • Strong Customer Satisfaction Focus
    • Team-oriented
    • Communication
    • Results
    • Problem Solving
    • MATHEMATICAL SKILLS

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  • IP and Corporate Paralegal

    Posted January 31, 2019

     

    Reporting to the Head of IP, Dicerna Pharmaceuticals is seeking an experienced paralegal with responsibilities for both the IP and Corporate legal operations in a fast-paced growth environment.

    Key Responsibilities

    • Coordinate, Track and Manage Internal Contracts and all associated deadlines.
    • Support implementation of contract management system and administer and maintain the system after implementation.
    • Insure compliance with active contractual agreements.
    • Facilitate the negotiation and execution of routine contracts on standard forms, such as CDAs.
    • Manage patent and trademark prosecution dockets and all associated deadlines.
    • Assist with compiling patent filings and electronically filing with the PTO.
    • Coordinate and prepare materials for Patent Committee meetings including agenda and minutes. Communicate with internal clients regarding patent prosecution requirements, procedures and status.
    • Coordinate prosecution instructions between internal counsel and outside counsel on a global level.
    • Assist with tracking and maintaining various corporate records, including internal policies.

    Qualifications

    To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the basic knowledge, skills, and/or abilities required.
    • Bachelor’s degree or equivalent or a degree in paralegal studies.
    • Minimum of 5-7 years of experience preparing and filing documents at the USPTO via e-filing including basic patent office transmittals, responses to missing parts, information disclosure statements, and responses to office actions; trademark exposure and/or experience working in a law firm is a plus.
    • Excellent knowledge of USPTO and PCT rules and filing procedures needed.
    • Experience with the CPi database, WORD and Excel. Experience with HUDL, Egnyte desirable.
    • Ability to work independently and take the initiative to accomplish objectives in a timely manner.
    • Demonstrated team player with willingness to collaborate and perform tasks outside of immediate job description when necessary to benefit the department as a whole.
    • Exposure to and Familiarity with Special Administrative Procedures – EP Oppositions, U.S. Post Grant Proceedings (Re-exams, IPRs) – First Instance and Appeals
    • Ability to interface directly with inventors to obtain necessary signatures on Declarations, Assignments and other necessary filing documentation.
    • Understanding Patent annuity system/prepare necessary quarterly annuity reports for sign off by the IP counsel – arranging for follow up payment in accordance with SOPs.
    • Experience with administrative duties associated with a contract management system desirable.
    • Experience with filing of SEC reports and facilitating the negotiation and execution of routine contracts desirable, but not necessary. Must have the willingness and ability to assist internal corporate legal team with preparing, processing and managing certain SEC filings and routine contracts.
    • Ability to handle multiple shifting priorities simultaneously.
    • Willingness to learn new skills and assume responsibility of additional tasks, as and when necessary.

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  • Scientist – Neuro Discovery

    Posted February 6, 2019

     

    Dicerna Pharmaceuticals is seeking a highly skilled PhD scientist to join their newly initiated Neuro Discovery group. This individual will be a key player in investigating the mechanism of action and pharmacological properties of Dicerna’s RNAi therapeutics in the central and peripheral nervous system.

    Key Responsibilities:

    • Leading internal and external research efforts to understand the mechanism of action and activity of siRNAs in the central and peripheral nervous system
    • Conducting siRNA drug candidate screening hit identification, and in vivo lead optimization
    • Preparing high quality technical reports and summaries for internal use and inclusion in key regulatory documents (e.g. INDs and NDAs)
    • Reviewing literature and providing insights to research directions, while predominantly making hands-on contributions to research

    Minimum Qualifications:

    • PhD in Neurology, Biology, Biochemistry, Pharmacology, or equivalent
    • 2+ years of experience in a relevant industrial or postdoctoral setting, with emphasis on the study of neurology or neurodegenerative disorders
    • Experience in handing rodents (mouse and rat)
    • Expertise in standard and high-throughput biological laboratory techniques. Key assays for this role include RT-qPCR, immunohistochemistry/immunofluorescence, ELISA, and Western blot
    • Experience in data analysis methods, including scientific software
    • Commitment to careful and thorough technical documentation, including electronic laboratory notebooks and study reports
    • Ability to interact effectively on multidisciplinary teams and participate in our exciting, dynamic company culture; ability to work independently

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  • New Product Planning Analyst/Manager

    Posted February 7, 2019

     

    We are seeking a New Product Planning Analyst/Manager to become a key member of Dicerna’s cross-functional development team for current and future clinical programs. Responsibilities span from product concept initiation to global commercialization.  This individual will lead the commercial assessment and develop the business case for our early development programs as well as gaining operating experience by participating in Dicerna’s business development activities. In the New Product Planning role you will become our internal domain expert in the commercialization of rare disease therapeutics and large patient population disorders. The successful candidate must have a proven track record of successfully working with other domain area experts in a cross-functional environment.

    Key Responsibilities

    • Lead the evaluation process for rare and large patient population disease programs
    • Develop and sustain a high degree of therapeutic knowledge about rare disease programs
    • Provide commercial direction by developing revenue forecasts, conducting market research, developing market access strategies, and brand positioning
    • Monitor marketplace developments and impact on Dicerna competitive position for commercialization
    • Build strong relationships with external experts, professional societies and patient advocacy groups for rare disease programs

    Qualifications

    • B.S./M.S. in a scientific discipline
    • 5+ years’ experience in a pre-commercial and marketing role in a biotech/ pharmaceutical company specializing in rare diseases
    • Strong business acumen and understanding of drug development
    • Demonstrated ability to multi-task across multiple projects
    • Able to perform in a fast-paced environment and manage multiple projects simultaneously
    • Excellent analytical, communication and presentation skills
    • Proven ability to work with cross-functional teams including research, development, regulatory, quality and clinical

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  • Vice President of Finance and Corporate Controller

    Posted February 8, 2019

     

    The Vice President of Finance and Corporate controller will lead the finance and accounting teams through the company’s rapid growth as it progresses through late stage clinical development into commercialization of its lead program and executes on its external collaborations. In this role he/she will drive the development and implementation of rigorous and standardized processes (systems, reporting, etc.) to enhance the quality of financial information used by key stakeholders for strategic decision making. He/she will oversee the accounting and financial reporting teams and advise the Chief Financial Officer on all technical reporting and operational accounting issues as the company experiences rapid growth. He/she will also be responsible for planning and execution of tax strategies for the Company.

    Key Responsibilities

    • Manage the scale up of the accounting and financial reporting functions to facilitate the Company’s growth.
    • Maintain focus on internal controls over financial reporting, continuous improvement of accounting policies and procedures, standardization of accounting practices, and compliance with US GAAP as well as local statutory requirements.
    • Oversee the accounting close and consolidation processes in close coordination with Director of Accounting.
    • Drive enhancement of financial reporting for the Company’s external collaborations and internal development programs.
    • Direct the preparation of the internal consolidated financial statements, including reports for the Board of Directors.
    • Implement and maintain budgetary and fiscal control over the Company’s spending
    • Oversee all public reporting and external financial reporting, including the annual report (10-K), quarterly reports (10-Q’s), Proxy Statement, other reports on form 8-K in close coordination with the Director of Financial Reporting.
    • Develop and oversee policies and procedures consistent with the Company’s financial objectives to support growth strategies, cost effectiveness, and compliance enforcement.
    • Communicate and enforce company-wide financial reporting policies, procedures and controls.
    • Assure compliance with the rules and regulations of the SEC including Sarbanes-Oxley.
    • Provide support to the CFO in overseeing the Audit and other Committees of the Board of Directors.
    • Manage the Company’s cash and investment portfolio
    • Work with tax advisors to develop and execute tax planning strategies for the company.
    • Oversee annual audit, quarterly review and tax return preparation.

    Qualifications

    • Bachelor’s Degree or higher in Business Administration, Finance or related discipline
    • CPA required. Big 4 Firm experience desired.
    • Fifteen or more years of financial, accounting and operational management with increasing levels of responsibility. Experience in a biotechnology/pharmaceutical industry desired.
    • SEC financial reporting experience required.
    • Demonstrated success collaborating with stakeholders in Finance, Manufacturing, Legal, R&D and an ability to continuously improve processes and develop efficiencies.
    • Experience in developing and improving financial systems which produce useful operating metrics.
    • Excellent presentation and communication with C-level executives.
    • Strong management, interpersonal and analytical skills essential with ability to be hands- on yet think long term and strategically.

     

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  • Research Associate/Associate Scientist-Chemical Development

    Posted March 8, 2019

     

    Dicerna Pharmaceuticals is seeking highly motivated scientists to join its Chemical Development team in Cambridge, Massachusetts. The candidates will be responsible for the development of purification technology for oligonucleotides and support analytical development for Dicerna’s oligonucleotides. Although the focus of the position will be purification development, this position will have the opportunity to contribute across a wide range of development activities including scale-up, analytical development and oligonucleotide synthesis.  Prior experience in oligonucleotide purification and/or analytical development is desired but not required.

    Key Responsibilities:

    • Purification and isolation of oligonucleotides utilizing state of the art techniques including reverse phase, ion-exchange and mixed mode medias
    • Prep samples, analyze and process data, primarily by HPLC
    • Development of new purification methods and approaches
    • Support transfer of new purification methods internally and to partner CMO’s
    • Contribute to analytical development activities
    • Operate and maintain lab instruments such as purification and HPLC systems
    • Conduct laboratory work in safe, efficient manner that ensures a safe working environment for colleagues
    • Complete assignments that meet deadlines and time schedules
    • Keep accurate records of the experiments and summarize the results in written reports

    Qualifications:

    • BS/MS in Chemistry, Biology or related field with 1-2 years of industrial experience
    • Experience in a cGMP environment is helpful
    • Knowledge of nucleic acids purification techniques and/or analytical development of oligonucleotide analysis methods.
    • Knowledge of nucleic acid chemistry and the synthesis of oligonucleotides is valuable, but not required
    • Experience with GE Akta purification systems is preferred
    • Experience with HPLC techniques on multiple platforms (e.g. Waters, Agilent, Thermo)
    • Possess excellent written and verbal communication skills
    • Ability to work as part of a multi-site team and possess an excellent work ethic
    • Ability to be successful in a fast-paced work environment

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  • Project Manager – PHXC (Colorado (Boulder Area))

    Posted March 19, 2019

     

    We are seeking a highly experienced and dynamic professional to manage drug development of the PHXC program as it relates to chemistry, manufacturing and controls. This individual will work closely with internal groups such as quality, manufacturing, supply chain, non-clinical and clinical and external stakeholders of the PHXC program to enable successful completion of program milestones.

    Key Responsibilities

    ·         Serve as project manager for PHXC program and provide tracking, coordination, and cross-functional communication to enable teams to meet goals.

    ·         Collaborate cross functionally with Dicerna internal teams such as Research, Regulatory, Nonclinical, Clinical, Manufacturing, Supply Chain and Quality.

    ·         Communicate development plans and track progress at external contract manufacturers and contract labs.

    ·         Apply project management best practices in the development, initiation, tracking, planning, execution, control and closing of PHXC projects.

    ·         Participate in development and sub-team meetings and assist as needed with agendas, project overviews, minutes, and action items.

    ·         Perform administrative tasks including creation and maintenance of project plans, meeting scheduling and facilitation, including agenda creation and tracking and communicating detailed meeting minutes with key decisions/action items.

    ·         Communicate and coordinate PHXC program activities as needed with internal and external stakeholders.

    • Develop and distribute periodic reports on performance, issues, risks, and schedules of key activities, events, or milestones.
    • Identify risks, brainstorm mitigation plans and facilitate resolution of issues adversely impacting the program.
    • Perform all above duties on other Dicerna programs and partnership programs as needed.

    Qualifications

    • BS degree in a science discipline. Advanced degree in the Life Sciences or related field preferred
    • Minimum of 10 years of relevant experience in pharmaceutical or biotechnology industry
    • Demonstrated experience in pharmaceutical drug development and minimum 3-5 years direct involvement with pharmaceutical project management
    • Excellent written and verbal communication skills. Expert skill level using MS Word, Excel, Project, and PowerPoint.
    • Strong problem-solving and organizational skills
    • Adept at managing competing priorities and timelines in a fast-paced, rapid-growth environment
    • Ability to work collaboratively with cross-functional teams, contractors and external regulatory agencies to drive results and meet company objectives
    • Ability to function independently as well as in a team-based environment
    • Minimal travel required

     

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  • Payroll Accounting Manager

    Posted March 19, 2019

     

    The Payroll Accounting Manager serves a critical role in ensuring the accurate and timely preparation and recording of payroll transactions as well as supporting the monthly close by booking journal entries and preparing supporting documentation.

    Key Responsibilities:

    ·         Process bi-monthly payroll.

    ·         Lead all payroll related audits (worker’s comp, etc).

    ·         Monthly, input standard journal entries into general ledger system, including rent, payroll, bonus, PTO and Headcount.

    ·         Prepare assigned balance sheet and income statement reconciliations.

    ·         Prepare reconciliations for all Benefits (Health spending, ESPP, etc).

    ·         Manage 401K plan.

    ·         Serve as ESPP administrator.

    ·         Administrate the time and expense reporting system (Unanet).

    ·         Monitor and comply with internal controls for payroll and financial reporting processes to ensure compliance with Sarbanes Oxley Act requirements.

    ·         Comply with local, state and federal payroll regulations and respond to questions and special requests from regulatory agencies.

    ·         Serve as the primary contact for payroll-related questions, concerns and inquiries.

    ·         Assist with accounting/finance process improvements.

    ·         Assist with ad hoc projects as required.

     

    Required skills and experience 

    ·         A Bachelor’s Degree in Accounting.

    ·         Five (5)+ years of applicable experience.

    ·         Knowledge of U.S. GAAP.

    ·         Experience with payroll and benefit accounting required.

    ·         Experience with multi-state payroll and familiarity with the reporting requirements.

    ·         Excellent communication skills, both written and verbal with the ability to work with all levels of management and employees.

    ·         Knowledge of ADP Workforce Now, Great Plains and Certent.

    ·         Excellent Excel and other Microsoft Office application skills.

    ·         Extremely well-organized and goal oriented with the ability to deliver results on time.

    ·         Willingness to be responsible for and perform tasks over a relatively wide spectrum; “roll-up-your-sleeves” attitude with a desire to advance career-wise.

    ·         Exceptional work ethic and unquestionable integrity.

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  • Senior HR Generalist

    Posted March 20, 2019

     

    Position Responsibilities:

    • Leadership of a diverse team, including all aspects of people management, selection, training, resource capacity, job design and performance management that creates high-performance operating environment
    • Work closely with Associate Director, Human Resources on Succession Planning for key talents and key job positions within area of responsibility.
    • May develop workflow and/or identify and implement new technology solutions to meet specialized needs of the assigned business function(s)
    • Contracts with outside suppliers to provide employee services, such as temporary employees, search firms, or relocation services.
    • Manages talent acquisition relationship with assigned business function(s), developing deep understanding of ongoing talent needs and resulting implications to talent acquisition to provide expertise and recommended solutions.
    • Assesses, addresses and triages employee questions and issues as needed. Delivers extraordinary customer service with internal employees as well as outside vendors.
    • Partners with SVP, HR and AD, HR to develop and present employee workshops and seminars.
    • Responsible for Reward and Recognition across the organization.
    • Researches, plans and helps implements Learning and Development throughout the organization.
    • Assists AD, HR with drafting, constructing and preparing HR employee communications: Newsletters, upcoming events and HR announcements
    • Identifies best practice workflows and streamline processes to increase efficiency across the Human Resources area.
    • Works on researching and developing updates and refinements to the Employee Resource Guide.
    • Assists with oversight of new employee onboarding process and benefits management

    Candidate Requirements:

    • Bachelor’s Degree
    • Minimum of 5-7 years of Human Resources operations experience.
    • High Level of interpersonal skills to handle sensitive and confidential situations and documentation
    • Strong business process aptitude and understanding; and highly developed analytical and reasoning skills.
    • Computer proficiency with MS Office Suite.
    • Must be able to work independently and part of a team, as well as handle multiple priorities in a fast-paced environment.
    • Highly developed and excellent verbal, written and presentation communication skills.

    Additional Information:

    • Travel requirements (%): 10%

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