Careers

Careers

At Dicerna, we foster a culture of innovation through collaboration.

View our list of career opportunities.

 

We are dedicated to benefiting patients by advancing science and developing creative solutions to challenging therapeutic problems. Our core values of dedication, innovation, communication, excellence, respect, needs based and accountability drive us personally and as a team, and these are critical factors in the long-term success of our company.

We encourage open dialogue to identify and act upon novel ideas to meet the urgent needs of patients.

As innovators in the emerging area of RNAi, we seek forward-thinking talent to join our growing team, advance our robust pipeline of therapies, and provide ground-breaking medicines to those that depend on us.

Our office location in Cambridge underscores our commitment to being an employer of choice in the Massachusetts life sciences sector, and to being in close proximity to world-class research, academic and healthcare institutions as well as other life sciences leaders. We play an active role in the biotechnology community and in the Alewife business community as the area undergoes a revitalization to become a mini life sciences and technology hub. Our office is close to the MBTA subway and buses, the 120-acre Alewife Reservation, as well as many restaurants and services.

 

Dicerna is proud to be an Equal Opportunity Employer.

For interest in future employment opportunities, please submit your resume to Megan Garrapy at mgarrapy@dicerna.com.

 

Career Opportunities

  • Medical Writer

    Posted January 18, 2018

     

    Reports to:                 Chief Medical Officer

    Overview

    The medical writer will be a key member of the Project Team and will work closely with Research, Clinical Operations and Regulatory Affairs to manage all aspects of document preparation for clinical and regulatory documents according to company guidelines and international governmental regulations. S/he will provide strategic direction to cross-functional teams to ensure that key messages are consistently aligned with reporting requirements and company objectives.

    Responsibilities  

    • Plan, prepare, write, edit, format, and finalize non-clinical, clinical and regulatory documents. Documents will include, but are not limited to: IND, CTA, non-clinical summaries, clinical protocols, clinical study reports, Investigator brochures, updates to regulatory submissions, annual reports/development safety update reports (DSURs) etc.
    • Assist in developing strategy for organizing and preparing documents for regulatory health authority submissions.
    • Coordinate the internal review of documents.
    • Develop, maintain, and drive document finalization timelines.
    • Ensure final document adheres to standard operating procedures (SOP), good clinical practice (GCP), and the International Council on Harmonisation (ICH).
    • Perform quality control review of medical writing documents
    • Assist in the development of templates, style guidelines, and SOPs for clinical documentation

    Requirements

    • Minimum requirement of a bachelor’s degree with 3-5 years of medical writing experience in a pharmaceutical/biotechnology or CRO environment
    • Ability to interpret and present clinical and non-clinical data objectively in a clear, concise format.
    • Outstanding written and oral communication skills
    • Proficiency in teamwork, organization, and project management
    • Proficiency in MS Office; experience using electronic document management system

    Upload Résumé (We prefer PDF format)

  • Research Associate

    Posted November 7, 2017

     

    We are seeking an experienced BS/MS scientist to help in our drug discovery efforts.  This is a hands-on, full-time, research position that requires strong expertise in molecular and cellular methodologies.

    Key Responsibilities

    • Independently test in vitro activity of drug candidates.
    • Maintain cell-cultures and perform cell-based assays.
    • Determine in vivo activity of hits from in vitro screens.
    • Effectively communicate results of experiments to project teams.
    • Maintain good written records of experiments, protocols and procedures.

    Qualifications

    • BS/MS in a relevant field with at least 2 years of academic or industry experience
    • Expertise in cellular and molecular biology is essential, specifically mammalian cell culture; cell-based assays; quantitative real-time PCR; western blotting; immunostaining
    • Experience with RNAi is preferable
    • Experience with in vivo methodologies e.g. mouse handling, dosing; sample analysis; disease modeling; histology is required
    • Strong verbal and written communications skills
    • Demonstrated ability to work as a team player in a dynamic environment.

    Upload Résumé (We prefer PDF format)

  • Associate Clinical Trial Manager

    Posted January 18, 2018

     

    Overview

    Join Dicerna Pharmaceutical’s Clinical Operations group as an Associate Clinical Trial Manager reporting to the Director of Clinical Operations.

    This is a unique opportunity to work closely with an experienced team interested in providing mentorship and learning opportunities to a motivated individual with a desire to grow within the clinical operations function.

    You will be responsible for the preparation of study related materials, relationship management between clinical sites and vendors, and identification of project risks and contingency planning.   You will assist in managing trials to ensure inspection readiness, timely and robust data collection, and assist the medical monitoring team with the maintenance of subject safety.

    Responsibilities:

    • Assist with Phase 2/3 Registrational Study and managing clinical trials within the development programs.
    • Work closely with the Contract Research Organization (CRO) study team
    • Assist with driving critical clinical trial timelines including trial site activations, recruitment, and database lock activities as well as assist in budget review and forecasting.
    • Work with the Director of Clinical Operations and study team to develop patient recruitment strategies, operational feasibility and implementation of study objectives.
    • Collaborate closely with the clinical operations team, including the Chief Medical Officer, and other key internal and external stakeholders (eg. Regulatory, Quality, pharmaceutical science). Coordinate activities between the clinical team, regulatory, pharmaceutical science and QA, internally and externally
    • Participate in the development of tools and metrics for monitoring clinical study progress and surveillance of key efficacy and safety data points.
    • Review corrective action plans at individual sites and provide oversight to ensure safety concerns are identified and responses developed.
    • Communicate trial status, issues, and mitigations to relevant cross-functional stakeholders.
    • Possible participate in internal/external study related audits
    • Manage critical study documents including but not limited to consent forms and study conduct documents.
    • Ensure study documents are submitted to the electronic trial master file (eTMF); assist with periodic audit of the eTMF.
    • Participate in contract and budget negotiations with clinical sites and study vendors.
    • Participate in development of protocols and investigator brochures.
    • Represent Dicerna during site initiation visits, trainings, close out visits, and conduct co-monitoring visits as needed
    • Assist with development of Standard Operating Procedures and templates for Clinical Operations.
    • Train study team members, monitors, and site staff as needed.

    Requirements:

    • BSN or Bachelor Degree in scientific discipline or health-related field
    • Minimum 4-5 years relevant clinical development experience in industry with at least 1 year of direct trial management experience
    • Experience with global clinical trial operations
    • Excellent knowledge of GCP, ICH and FDA regulations
    • Experience in Rare Disease and Pediatric trials preferrable
    • Experience with all aspects of trial and site startup and vendor management
    • Familiarity with clinical data review and data management processes, including Data Monitoring Committees
    • Ability to deal with competing/changing priorities, work on teams with aggressive timelines and multi-task in a fast-paced environment with attention to detail
    • Ability to find creative solutions to issues impacting timelines and budgets
    • Strong verbal and written communication skills
    • Must be willing to travel up to 20%, domestically and internationally
    • Proficient in MS Office (Excel, PowerPoint and Word)

    Upload Résumé (We prefer PDF format)

  • Associate Scientist I

    Posted February 5, 2018

     

    Associate Scientist I sought by Dicerna Pharmaceuticals, Inc., a biopharmaceutical company focused on the discovery and development of innovative RNAi-based therapeutics for diseases involving the liver, to independently implement and perform in-vitro tritosome assay using high resolution mass spectrometry to support new chemistry SAR screening for DsiRNA conjugates. Prepare and manufacture lipid nanoparticle (LNP) formulations to support both in-house in vivo studies in various orthotopic and sub-cutaneous tumor models and external collaborations, including academic labs and National Cancer Laboratories. Perform routine analytical assays for characterizing LNP formulations in terms of particle size, zeta potential, and payload encapsulation. Independently explore, optimize, and develop LNP formulation process, including pump configuration for in-line mixing and formulation purification techniques such as ultracentrifugation, dialysis, and tangential flow filtration (TFF). Independently develop and optimize LNP analytical characterization assays using Reverse-phase/Ion-Exchange/Size-Exclusion Liquid chromatography (HPLC/UPLC) for siRNA quantification and UPLC-Charged Aerosol Detector (CAD) for quantitative lipid analysis. Plan and perform pilot short- and long- term formulation stability studies, and identify degradation profiles. Perform routine mass spec data processing and visualization, as well as data summary and presentation. Contribute to development of Bio-Registration software for metabolism identification data processing. Plan and conduct pilot stability study of lead DsiRNA conjugate drug product. Support QC method evaluation for external CMOs for CMC purposes.

    Position located in Cambridge, MA

    Requirements include a Bachelor’s degree or equivalent in Pharmaceutical Sciences, Chemistry, Analytical Chemistry or related field and eight years of work experience in the job offered or related field of Pharmaceuticals or Biotechnology; or, in the alternative, a Master’s degree or equivalent and five years of pre-or post-degree work experience.

    Upload Résumé (We prefer PDF format)

  • Scientist/Sr. Scientist, Synthetic Chemistry

    Posted January 24, 2018

     

    Overview

    Dicerna is a biopharmaceutical company focused on the discovery and development of innovative treatments for rare diseases, chronic liver diseases, cardiovascular disease, and viral liver infectious diseases.  The Company is using its proprietary GalXC™ RNAi technology platform to build a broad pipeline in these therapeutic areas.

    We are seeking a highly skilled and motivated synthetic chemist able to function in a fast-paced, collaborative environment. The successful candidate will be a member of the chemistry team responsible for the synthesis of nucleoside analogues and oligonucleotide conjugates and will work closely with contract research/manufacturing organizations on the scale-up and tech transfer of processes. The incumbent will also help to further develop and implement our analytical/MetID strategy to assist in the optimization of our GalXC conjugates.

    Key Responsibilities

    • Design, plan and execute multi-step organic synthesis and purification of high quality target molecules.
    • Review research papers and intellectual property literature and propose novel target molecules.
    • Operate and maintain multiple instrumentation including HPLC, LCMS for purification, characterization and purity determination of prepared compounds.
    • Metabolic profiling and assessing the stability of oligonucleotides in cellular, sub-cellular and biological tissue extracts.
    • Assist in the planning and management of external research efforts for contract research organizations and collaborations.
    • Function as a senior member of the chemistry group aiding in the preparation of intellectual property, publications, and project planning.

    Qualifications

    • Ph.D. in organic chemistry with 1-7 years of relevant experience.
    • In-depth knowledge of organic chemistry reactions and mechanisms.
    • Experience with chromatography techniques i.e. LC-MS, ion exchange and RP-HPLC.
    • Thorough understanding of analytical techniques (HPLC, LC-MS) for characterization of nucleoside and oligonucleotide compounds.
    • Ability to work independently and collaboratively in a fast-paced, matrixed, team environment consisting of internal and external team members.
    • Experience in heterocyclic and/or carbohydrate chemistry, familiarity with nucleoside synthesis, bio conjugate chemistry is preferred along with knowledge in oligonucleotide chemistry.
    • Experience in the bioanalysis and quantitation of drug levels in biological matrices and familiarity with oligonucleotide bioanalysis.

    Upload Résumé (We prefer PDF format)

  • Sr. Quality Assurance Specialist/Quality Assurance Manager

    Posted January 24, 2018

     

    Overview

    Dicerna is a biopharmaceutical company focused on the discovery and development of innovative treatments for rare diseases, chronic liver diseases, cardiovascular disease, and viral liver infectious diseases.  The Company is using its proprietary GalXC™ RNAi technology platform to build a broad pipeline in these therapeutic areas.

    We are seeking a key individual to help develop our quality management system and to build a culture of quality throughout the organization.  This individual will manage and oversee the Document Management System, Training System and other QMS.  This individual in this role will also be responsible for managing the portfolio of quality system validation projects based on corporate goals.

    Key Responsibilities

    • Ensure quality activities are carried out according to regulatory requirements.
    • Perform external audits and study audits to assess compliance with Good Manufacturing Practices (GMP), Good Laboratory Practices (GLP) and approved Standard Operating Procedures (SOPs).
    • Assist with coordinating vendor audits and process/ critical phase audits.
    • Maintain all documents/ protocols/ plans including archival.
    • Assist in coordinating and managing the configuration and implementation of quality systems/technologies (processes and toolsets).
    • Work with subject matter experts to identify enhancements to business processes and system design, suggest solutions for implementation.
    • Ensure deviations from batch records, protocols, sample analysis plans, or SOPs are documented and properly authorized.
    • Track the investigation/resolution of Corrective and Preventive Actions (CAPA) and deviations.
    • Monitor and author Quality Assurance standard operating procedures (SOPs) as required.
    • Evaluate vendors to assure compliance to required regulations and project needs.
    • Assist with ensuring that client audit reports are responded to in a timely manner.
    • Provide GxP training and guidance to staff.
    • Represent QA on relevant operations teams.

    Qualifications

    • BS/BA in science related field with 5 + years of related Quality Assurance experience.
    • 3-5+ years of auditing experience in a Quality Assurance related function.
    • Knowledge of GLP, GMP, GCP, Part 11 regulations, FDA Guidance for Industry, EU regulations and regulatory requirements for computer system validation.
    • Working knowledge of QMS.
    • Understanding of and ability to verify scientific text and data.
    • Strong problem solving and analytical skills.
    • Ability to think strategically and maintain attention to detail.
    • A problem solver able to interact at all levels of the organization.
    • Demonstrated ability to manage multiple priorities simultaneously and work effectively in a fast paced environment.
    • Excellent written and verbal communication skills, strong negotiation and decision making ability.
    • Knowledge of Microsoft Office® applications including Excel, Word, Power Point, and Microsoft Project.

    Upload Résumé (We prefer PDF format)

  • New Product Planning Analyst/Manager

    Posted January 31, 2018

     

    We are seeking a New Product Planning Analyst/Manager to become a key member of Dicerna’s cross-functional development team for current and future clinical programs. Responsibilities span from product concept initiation to global commercialization.  This individual will lead the commercial assessment and develop the business case for our early development programs as well as gaining operating experience by participating in Dicerna’s business development activities. In the New Product Planning role you will become our internal domain expert in the commercialization of rare disease therapeutics. The successful candidate must have a proven track record of successfully working with other domain area experts in a cross-functional environment.

    Key Responsibilities

    • Lead the evaluation process for rare disease programs
    • Develop and sustain a high degree of therapeutic knowledge about rare disease programs
    • Provide commercial direction by developing revenue forecasts, conducting market research, developing market access strategies, and brand positioning
    • Monitor marketplace developments and impact on Dicerna competitive position for commercialization
    • Build strong relationships with external experts, professional societies and patient advocacy groups for rare disease programs

    Qualifications

    •  B.S./M.S. in a scientific discipline
    • 5+ years’ experience in a pre-commercial and marketing role in a biotech/ pharmaceutical company specializing in rare diseases
    • Strong business acumen and understanding of drug development
    • Demonstrated ability to multi-task across multiple projects
    • Able to perform in a fast-paced environment and manage multiple projects simultaneously
    • Excellent analytical, communication and presentation skills
    • Proven ability to work with cross-functional teams including research, development, regulatory, quality and clinical

     

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