Board of Directors
Providing a strategic vision for the future.
Douglas M. Fambrough, III Ph.D.
Chief Executive Officer
Douglas M. Fambrough, III Ph.D. co-founded Dicerna in 2007 and has served as the Company’s chief executive officer since 2010. Prior to joining Dicerna as CEO, Doug specialized in financing innovative life science technology companies as a general partner with Oxford Bioscience Partners, a Boston-based venture capital firm.
In 2003, Doug and two other investors founded Sirna Therapeutics, a first-generation RNA interference (RNAi) pioneer; he served on Sirna’s Board of Directors until the company was acquired by Merck for $1.1 billion in 2006. Other investments include Solexa, developer of the dominant ultra-high-throughput DNA sequencing platform, acquired by Illumina for $600 million; and Cambrios Technologies, which invented and now markets biologically inspired electronic materials for touch screens and flat panel displays. Before joining Oxford, Doug was a genomic scientist at the Whitehead/MIT Center for Genome Research (now known as the Broad Institute).
Doug graduated from Cornell University and obtained his Ph.D. in genetics at the University of California, Berkeley.
Martin Freed, M.D.
Martin Freed, M.D., has been a member of the Dicerna board of directors since 2016 Dr. Freed has served as an independent consultant to several private pharmaceutical, biotechnology, and healthcare companies, specializing in clinical and general pharmaceutical development and clinical and regulatory strategy since February 2015.
He co-founded and served as chief medical officer of Civitas Therapeutics, Inc., from December 2010 to October 2014 (acquired by Acorda Therapeutics, Inc., or Acorda) and as senior vice president, clinical development of Acorda from October 2014 through January 2015.
In addition, Dr. Freed has served as chief medical officer and has provided strategic and operational planning and execution, as well as medical leadership for clinical pharmacology and development strategy and preclinical development for multiple pharmaceutical companies throughout his career. These companies include Avila Therapeutics, Inc., Taligen Therapeutics, Adnexus Therapeutics, Inc.,(acquired by Bristol-Myers Squibb), and Vitae Pharmaceuticals, Inc.
Dr. Freed spent nearly 14 years at GlaxoSmithKline and its predecessor, SmithKline Beecham Pharmaceuticals or SmithKline Beecham, where he served numerous roles including vice president, clinical development and medical affairs in the metabolism therapeutic area. He has authored over 100 publications or presentations.
Dr. Freed has been Board Certified in Internal Medicine, Nephrology and Clinical Pharmacology. He performed his internal medicine residency at Temple University Hospital and nephrology fellowship at Yale-New Haven Hospital. A Fellow of the American College of Physicians, Dr. Freed received his B.S. with Distinction in Biology from the University of Delaware and M.D. from Pennsylvania State University’s College of Medicine.
Brian Halak, Ph.D.
Partner, Domain Associates
Brian Halak, Ph.D. joined Domain in 2001 and became a partner in 2006. From 2000 to 2001, he was an associate with Advanced Technology Ventures, where he participated in the firm’s investments in Plexxikon, Percardia and Emphasys. Previously, Brian was a consultant at the Wilkerson Group, where he developed strategy for pharmaceutical and medical device companies.
Brian is currently a member of the Investment Advisory Council for Ben Franklin Technology Partners and BioAdvance, both of which are seed-stage investment groups in Philadelphia.
Brian holds a Ph.D. in immunology from Thomas Jefferson University and a B.S. in engineering from the University of Pennsylvania.
Stephen Hoffman, M.D., Ph.D.
Senior Advisor, PDL BioPharma
Stephen Hoffman, M.D., Ph.D. has been a senior advisor to PDL BioPharma since February 2014. Previously, he served as a managing director at Skyline Ventures from May 2007 until February 2014. From January 2003 to March 2007, Stephen was a general partner at TVM Capital. Prior to that, he served as president, chief executive officer and a director of Allos Therapeutics from 1994 to 2002, where he remained as chairman of the board until 2012.
Stephen was the scientific founder of Somatogen, which was acquired by Baxter in 1998; he held the position of vice president of science and technology at Somatagen from 1987 until 1990.
In addition to Dicerna, Stephen serves on the board of directors of Genocea Biosciences. Previously, he served on the board of directors of Allos Therapeutics, which was acquired by Spectrum Pharmaceuticals in 2012, and Sirtris Pharmaceuticals, which was acquired by GlaxoSmithKline in 2008.
Stephen holds a Ph.D. in bio-organic chemistry from Northwestern University and an M.D. from the University of Colorado School of Medicine. He completed a fellowship in clinical oncology and a residency and immunodermatology fellowship in dermatology, all at the University of Colorado.
Peter Kolchinsky, Ph.D.
Partner, RA Capital
Peter Kolchinsky, Ph.D. is a co-founder and general partner of RA Capital Management, which has been investing in healthcare companies since 2002. He has served as a member of the National Academies Board on Global Science and Technology, authored an e-book titled, “The Entrepreneur’s Guide to a Biotech Startup,” and serves as an advisor to startup companies and non-profits.
Peter received his undergraduate degree in biology from Cornell University and a Ph.D. in virology from Harvard University, where he conducted research at Dana-Farber Cancer Institute on the entry mechanism of the human immunodeficiency virus (HIV).
Dennis Langer, M.D., J.D.
Director, Dicerna Pharmaceuticals
Dennis Langer, M.D., J.D. has been a director of Dicerna Pharmaceuticals since 2007 and of Myriad Genetics since 2004. He was previously senior vice president in research and development at GlaxoSmithKline and has a broad base of experience in innovative R&D companies such as Eli Lilly, Abbott and GD Searle.
He is also a clinical professor in the Department of Psychiatry at Georgetown University School of Medicine.
Dennis holds a J.D. (cum laude) from Harvard Law School, an M.D. from Georgetown University School of Medicine and a B.A. in biology from Columbia University.
David M. Madden
Chairman of the Board of Directors Dicerna Pharmaceuticals Founder and Principal, Narrow River Management
David Madden has been chairman of the board of directors of Dicerna Pharmaceuticals since 2009. He is a founder and principal with Narrow River Management, LP, an investment management company with a focus on equity investments in the emerging pharmaceutical industry.
From 2000 to 2003, David was co-CEO of Royalty Pharma AG, a private investment management firm specializing in the acquisition of royalty interests in pharmaceutical products. Prior to that position, he was a managing member of Pharmaceutical Partners, LLC, and was president, CEO and a director of Selectide Corporation, a development-stage pharmaceutical company, which was acquired by Marion Merrill Dow in 1995. Additionally, David serves as chairman of the board of Adolor Corporation, and is a member of the board of directors of the Hospital for Special Surgery in New York City.
David holds a B.S. in electrical engineering from Union College and an M.B.A. from Columbia University.
Director, Dicerna Pharmaceuticals
Bruce Peacock served as chief executive officer of Alba Therapeutics, The Little Clinic, Adolor Corp. and Orthovita Inc. Bruce also served as chief operating officer of Cephalon Inc., chief financial and business officer of Ophthotech, and chief financial officer of Centocor Inc. Additionally, he is co-chair of Alba Therapeutics, and a member of the board of directors of Discovery Laboratories Inc., Ocular Therapeutix and Invisible Sentinel Inc. Bruce holds a B.A. from Villanova University and is a certified public accountant.