Careers

Careers

At Dicerna, we foster a culture of innovation through collaboration.

View our list of career opportunities.

 

We are dedicated to benefiting patients by advancing science and developing creative solutions to challenging therapeutic problems. Our core values of dedication, innovation, communication, excellence, respect, needs based and accountability drive us personally and as a team, and these are critical factors in the long-term success of our company.

We encourage open dialogue to identify and act upon novel ideas to meet the urgent needs of patients.

As innovators in the emerging area of RNAi, we seek forward-thinking talent to join our growing team, advance our robust pipeline of therapies, and provide ground-breaking medicines to those that depend on us.

Our office location in Cambridge underscores our commitment to being an employer of choice in the Massachusetts life sciences sector, and to being in close proximity to world-class research, academic and healthcare institutions as well as other life sciences leaders. We play an active role in the biotechnology community and in the Alewife business community as the area undergoes a revitalization to become a mini life sciences and technology hub. Our office is close to the MBTA subway and buses, the 120-acre Alewife Reservation, as well as many restaurants and services.

 

Dicerna is proud to be an Equal Opportunity Employer.

For interest in future employment opportunities, please submit your resume to Megan Garrapy at mgarrapy@dicerna.com.

 

Career Opportunities

  • Bioanalytical Chemist

    Posted March 6, 2018

     

    Overview 

    Dicerna is seeking an experienced Bioanalytical Chemist specializing in solving challenges in the analysis of molecular biomarkers and metabolites with a range of techniques and equipment. Experience in the bioanalysis and quantitation of oligonucleotides in biological matrices is a plus but is not required if balanced by a demonstrated breadth of bioanalytical experience. 

    Key Responsibilities 

    • Method development and quantitation of oligonucleotides in biological matrices including plasma, liver, and urine.
    • Operation and hands-on troubleshooting of multiple types of analytical instrumentation including HPLC, UPLC and LC-MS instruments.  
    • Method development for biomarker analysis.
    • Assist in the planning and management of contract research organizations and collaborations for the outsourcing of oligonucleotide bioanalysis. 
    • Technical support to non-clinical and clinical development activities including drafting and reviewing study reports for IND and CTA.

    Qualifications 

    • Ph.D. in Analytical Chemistry, Chemistry or Biochemistry with at least 3 to 5 years of relevant industrial experience in DMPK, biomarker and metabolite identification. 
    • Proficiency in mass spectrometry for metabolite profiling and identification.  
    • Experience with multiple types of analytical and chromatographic separation techniques, i.e. RP-HPLC, HILIC, SAEX and SEC. 
    • Strong computer skills and experience with software driven metabolite profiling is required. 
    • The successful candidate must be a resourceful and proactive individual who is able to work as a team player in a dynamic environment with tight deadlines. 

    Upload Résumé (We prefer PDF format)

  • Director, Investor and Public Relations

    Posted September 11, 2018

     

    The Director, Investor and Public Relations will work directly with senior company executives to develop and implement Dicerna’s investor and public relations strategy. The position will be responsible for managing external relationships and assuring strong and consistent communication with the investment community including current shareholders, prospective shareholders, and financial analysts covering the company as well as serve as the company contact and spokesperson to the media.

     

    Key Responsibilities

    • Interact with the investment community on behalf of Dicerna and be proficient at communicating the company mission.
    • Establish and maintain excellent relations with institutional investors, key retail investors and analysts
    • Serve as the main point of contact for media
    • Develop, implement and manage strategic investor and public relations plans and manage the activities of agencies (IR, PR, etc.) working on behalf of Dicerna
    • Develop press releases, Q&A documents, messaging and other relevant materials to support public disclosures
    • Develop key communication materials in collaboration with senior leadership in preparation of analyst events, presentations, road shows, earnings releases and other announcements
    • Manage Dicerna’s corporate communications via the website and social media channels.
    • Update and continuously improve the website and social media efforts ensuring that key messages and communications are consistent.
    • Represent Dicerna at financial and industry conferences and medical meetings including coordinating meeting schedules and participating in one-on-one meetings with investors
    • Provide review and commentary on SEC filings including the annual report
    • Serve as key point of corporate communications to internal employees

    Qualifications

    • BA or BS required, MBA preferred
    • Minimum 10 years of experience working for a pharmaceutical/biotech company including experience in investor and/or public relations, corporate strategy, equity research, investment banking, finance or corporate communications
    • Stellar verbal and written communication skills, including impeccable presentation skills; proven ability to effectively interact with and present (verbally and in writing) to external and internal stakeholders. Demonstrated through a personable and energetic communication style with the ability to convey credibility.
    • Successful track record of interfacing with the investment community and media
    • Uncompromising ability to maintain confidentiality, exercise sound judgment and the highest level of discretion; knowledge of SEC and disclosure requirements preferred
    • Ability to demonstrate initiative and simultaneously achieve multiple tasks

    Upload Résumé (We prefer PDF format)

  • Clinical Project Manager

    Posted August 1, 2018

     

    Position Description

    This is a unique opportunity to work in a growing department that manages multiple early-stage clinical programs based on an innovative RNAi technology platform. We are looking for several passionate and collaborative individuals who will be responsible for all aspects of clinical trial management aimed at treating a rare or infectious liver-targeted disease.    You will be responsible for the successful execution of clinical trials from protocol finalization through closeout.

     

    Responsibilities:

    • Oversee performance of CROs, third party vendors, and contractors, including co-monitoring, to ensure compliance with study protocol, and identifying areas of concern and escalating to Clinical Program Lead when appropriate.
    • Collaborate with the Clinical Program Lead and study team to develop patient recruitment strategies, operational feasibility and implementation of study objectives.
    • Develop study plan(s) including key milestones and timelines.
    • Ensure country and site selection meet study requirements.
    • Participate in development and testing of clinical systems (e.g., data capture, IxRS).
    • Ensure internal and external systems are updated in a timely manner (e.g., trackers, clinicaltrials.gov).
    • Manage critical study documents, such as consent forms, study manuals, subject recruitment materials.
    • Oversee the Trial Master File and assist with periodic audit of the TMF.
    • Drive critical clinical trial activities including trial site activations, recruitment, and database lock.
    • Assist in contract and budget negotiations with clinical sites and vendors as well as budget review and forecasting.
    • Independently manage interactions with clinical monitors, data management, safety, regulatory, pharmaceutical science and QA team members, both internally and externally.
    • Participate in the development of tools and metrics for monitoring clinical study progress and surveillance of key efficacy and safety data points.
    • Collaborate with other functions (at CRO or internally) to ensure robust plans for study level data review, including trend evaluation.
    • Provide input in internal/external study related audits, review resulting reports.
    • Review monitoring reports and, if applicable, corrective action plans at individual sites and provide oversight to ensure safety concerns are identified and responses developed.
    • Communicate trial status, issues, and mitigations to relevant cross-functional stakeholders.
    • Represent Dicerna during site initiation visits, trainings, close out visits, and conduct co-monitoring visits as needed.
    • Train study team members, external monitors, and site staff as needed.

     

    Requirements:

    • BSN or Bachelor’s Degree in scientific discipline or health-related field
    • Minimum 5 years clinical development experience in industry with at least 2 years as trial manager
    • Experience with global clinical trial operations, in multiple phases of research
    • Strong knowledge of GCP, ICH and FDA regulations
    • Experience with all aspects of trial and site startup and vendor management
    • Ability to deal with multiple priorities having aggressive timelines with attention to detail
    • Ability to find creative solutions to issues impacting timelines and budgets
    • Willingness to travel up to 20%, domestically and internationally
    • Proficient in MS Office (Excel, PowerPoint and Word)
    • Experience in Rare Disease, Pediatric, and/or complex clinical trials preferred

    Upload Résumé (We prefer PDF format)

  • Director, Program Development

    Posted August 27, 2018

     

    Location:   Boulder, CO/Cambridge, MA

     

    The Director, Program Development is an experienced professional with demonstrated ability to manage drug development programs ranging from early to late stages.  The individual will be responsible for managing Dicerna development programs and enable successful completion of program milestones and corporate goals.  This role is highly cross-functional and may involve close interaction with external partners.

     

    Key Responsibilities

    • Serve as program manager for Dicerna development programs and provide leadership, coordination, and cross-functional communication to enable teams to meet goals. This includes:
    • Leading and participating in development and subteam meetings
    • Applying program management best practices in the development, initiation, tracking, planning, execution, and control of programs.
    • Performing administrative tasks including creation and maintenance of program plan documents, meeting scheduling and facilitation, and developing and tracking detailed program budgets
    • Coordinate with other program managers to ensure document continuity, assign appropriate resource allocation, and improve Development team processes.
    • Collaborate cross functionally with Research, Regulatory, Quality, Nonclinical, Clinical and Manufacturing to facilitate information flow and communication between all stakeholders and to ensure execution of program strategy
    • Identify and creatively facilitate resolution of issues adversely impacting programs
    • Compile appropriate metrics, tracking reports and provide updates to senior management to ensure programs are adequately resourced to meet strategic objectives
    • Provide program management support to the rest of the organization as requested

     

    Qualifications

    • BS degree in a science discipline with a minimum of 10 years relevant experience or an MS/Ph.D. with 8 years relevant experience
    • Previous experience managing drug development programs, experience with late stage programs a plus
    • Knowledge of global regulatory guidances (e.g. ICH and geography-specific) and Good Laboratory Practice (GLP) standards
    • Experience preparing regulatory filings such as INDs/CTAs/NDAs
    • Proficiency with Microsoft Office including Microsoft Project
    • Demonstrated ability to translate strategy into action
    • Ability to find creative solutions to issues impacting timelines and budgets
    • Ability to analyze and communicate complex issues, develop plans, programs and recommendations
    • Excellent organizational and communication skills – both oral and written
    • Highly collaborative team player who fosters open communication and develops important relationships with key stakeholders
    • Ability to lead cross-functional drug development
    • Ability to use collaborative technology to lead virtual meetings and work with team members around the world
    • Must be able to effectively organize and multi-task in a fast-paced environment
    • PMP certification would be a plus, but is not required
    • Some travel (domestic and international) will be required depending on program needs

     

    Upload Résumé (We prefer PDF format)

  • Nonclinical Writer

    Posted August 27, 2018

     

    Location:    Cambridge, MA or Boulder, CO

     

    The Nonclinical Writer will be a key member of the Program Development Team and will work closely with Nonclinical and ADME to manage all aspects of preparation for regulatory documents according to company guidelines and international governmental regulations. The individual will provide strategic direction to cross-functional teams to ensure that key messages are consistently aligned with reporting requirements and company objectives.

     

    Responsibilities  

    • Plan, prepare, write, edit, format, and finalize nonclinical and ADME regulatory documents. Documents will include, but are not limited to: IND, CTA, summaries and updates to regulatory submissions, annual reports/development safety update reports (DSURs) etc.
    • Work with program development teams and the medical writing staff to assist in developing strategy for organizing and preparing documents for regulatory health authority submissions
    • Coordinate the internal review of nonclinical documents
    • Develop, maintain, and drive document finalization timelines
    • Ensure final documents adhere to internal standard operating procedures (SOP) and the International Council on Harmonisation (ICH)
    • Perform quality control review of writing documents
    • Assist in general document formatting and word processing as needed
    • Assist in the development of templates, style guidelines, and SOPs for documentation

     

    Requirements

    • Minimum requirement of a bachelor’s degree with 4+ years of nonclinical writing experience in a pharmaceutical/biotechnology or CRO environment
    • Ability to interpret and present non-clinical data objectively in a clear, concise format
    • Outstanding written and oral communication skills
    • Proficiency in teamwork, organization, and project management
    • Proficiency in MS Office

    Upload Résumé (We prefer PDF format)

  • Data Manager

    Posted September 10, 2018

     

    Overall responsibilities will include oversight of clinical data management (CDM) activities for the entire Dicerna clinical portfolio. The successful candidate will proactively oversee CDM execution of CRO outsourced trials from study startup through study closure in support of trial objectives and corporate goals. This position reports to the Director of Biometrics.

    Key Responsibilities

    • Provide oversight of clinical data management activities across multiple studies.
    • Collaborate with clinical study teams and vendors to meet project deliverables, including data acquisition, quality checking and reporting in compliance with GCP, SOPs and regulatory requirements.
    • Oversee the development of study-specific CDM documentation such as eCRF specifications, eCRF completion guidelines, annotated CRFs, edit check specifications, and data management plans – identifying and mitigating risks to data quality.
    • Oversee the activities of CRO DM functional counterparts to ensure adherence to scope of work and service agreements, and to ensure deliverables are met in accordance with study milestones/timelines and with quality.
    • Participate in selection of CROs and vendors; review proposals and make award recommendations
    • Perform thorough development testing of the eCRF prior to deployment, inclusive of creating User Acceptance Test (UAT) Plans, Test Scripts and execute testing as applicable.
    • Ensure completeness, accuracy and consistency of clinical data across all assigned studies.
    • Participate in internal study team meetings as well as teleconferences with outside vendors and study personnel.
    • Report query trends and data/query metrics to the study team.
    • Review data transfers for consistency with available specifications, e.g. SDTM specifications, annotated CRFs.
    • Represent data management at Investigator Meetings and may present EDC and Case Report Forms to investigators.
    • Implement, track and review key performance indicators on data entry, source verification, and query status; perform quality control on those metrics to ensure accuracy.
    • Participate in study document reviews, e.g. clinical study protocols, statistical analysis plans, Mock Tables, Figures and Listings (TFL) shells.
    • Review draft TFL output prior to final database locks.
    • Contribute to the development of data standards in compliance with CDISC (CDASH/SDTM), and corresponding standard edit checks and data review listings.
    • Participate in the review and/or development of SOPs and working practices.

    Qualifications

    • BS/BA in Life Science or related discipline
    • 5+ years of clinical data management experience in the pharmaceutical/CRO industry.
    • 5+ years of Electronic Data Capture (EDC) experience
    • Global clinical trial and CRO management experience
    • Strong working knowledge of FDA & ICH/GCP regulations and guidelines
    • Strong working knowledge of CDISC standards (CDASH and SDTM) and CDM Best Practices.
    • Experience with SAS or SQL programming techniques with clinical data management application a plus.
    • Demonstrated ability to work independently to manage complex projects with multiple priorities in a fast paced, team-based environment

    Upload Résumé (We prefer PDF format)

  • Quality Assurance Specialist

    Posted September 10, 2018

     

    Dicerna is looking for a Sr. Quality Assurance Specialist who will manage and oversee the Document Management System, Training System and other QMS as deemed required for execution and maintenance (data entry, reporting, filing, archival) of the assigned quality system. Acts as technical resource for Quality while tracking and trending of investigation/resolutions of Corrective and Preventive Actions (CAPA) and deviations.  They also must have a working knowledge of QMS and its responsibilities and be a self-starting problem solver who drives results through high compliance and a positive work style ensuring quality activities are carried out according to the regulatory requirements.

    Key Responsibilities

    • Ensure quality activities are carried out according to the regulatory requirements.
    • Manage and oversee the Document Management System, Training System and other QMS as deemed required.
    • Track the investigation/resolution of Corrective and Preventive Actions (CAPA) and deviations.
    • Has a working knowledge of QMS and its responsibilities.
    • Be a self-starting problem solver who drives results through high compliance and a positive work style.
    • Manage and oversee the Document Management System that would include Edit document formatting without changing content to ensure consistency across documents.
    • Coordinate workflows with task owners to ensure that documents are properly reviewed, issued, approved, and obsoleted within needed timeframes.
    • Follow up with others to ensure that records are completed and documented within established timeframes.

    Qualifications

    • BS/BA in science related field or equivalent experience with 5 + years of related Quality Assurance experience.
    • 3-5+ years of document management experience in a Quality Assurance related function.
    • Knowledge of GLP, GMP, GCP, Part 11 regulations, FDA Guidances for Industry, EU regulations, and other standards.
    • Strong proofreading and document formatting skills which must include processing of controlled documents (new documents, revision, obsolescence, etc.)
    • Strong problem solving/analytical skills.
    • Knowledge of Microsoft Office® applications and spreadsheet programs such as Excel, Word, Power Point, and Microsoft Project.
    • Excellent abilities with intermediate MS office concepts such as Word Styles, cross-references, keep with next, section breaks, freeze panes, header/footer and others
    • The ability to work independently with minimal supervision, interact with staff (at all levels) in a fast-paced environment, sometimes under pressure, remaining flexible, proactive, resourceful and efficient, with a high level of professionalism.
    • Excellent written and verbal communication skills, strong negotiation and decision-making skills, and attention to detail are equally important.
    • The ability to comprehend regulations and guidance documents and apply critical thinking skills to evaluate requirements and effectively communicate written and oral findings.
    • Strong organizational skills, with the ability to handle multiple tasks.

    Upload Résumé (We prefer PDF format)

  • ADME Manager

    Posted September 14, 2018

     

    Location: Boulder, CO/Cambridge, MA

    We are seeking an ADME Manager to help advance the development of our growing pipeline of product candidates.  The individual in this position will assist in the oversight of bioanalytical studies conducted at external contract research organizations (CRO).

    Key Responsibilities

    • Responsible for management, operational oversight, and may be involved with on-site monitoring of bioanalytical studies conducted at CROs
    • Serve as the point person for managing study communications, activities, and documents from Request for Proposal (RFP) to study closure. This includes keeping team electronic file storage sites up to date.
    • In partnership with the nonclinical team, contribute to study designs, protocol development, and written reports. Draft CTD tables from study data.
    • Facilitate review and compilation of feedback from stakeholders for study related documentation. Provide QC of tables and reports as needed.
    • Work closely with CROs to ensure that all studies are performed in a high quality and timely manner in order to meet program goals
    • Facilitate study-related shipments and data transfer
    • May participate in CRO evaluation and qualification
    • May contribute to the preparation of nonclinical components for regulatory submissions
    • Collaborate cross functionally with Research, Regulatory, Clinical, and Manufacturing and relevant program team
    • Communicate bioanalytical timelines and data to stakeholders as needed
    • Some travel (domestic and international) will be required depending on project needs

    Qualifications

    • S. in a scientific discipline, bioanalytical or ADME-related discipline preferred, with 5-7 years of pharmaceutical industry or CRO experience
    • Experience with oligonucleotides preferred but not required
    • Knowledge of global regulatory guidances (e.g. ICH and geography-specific) and Good Laboratory Practice (GLP) standards
    • With attention to detail, ability to critically evaluate all study documentation (e.g. protocols, data, reports)
    • Ability to determine test article needs and calculate or confirm solution calculations
    • Effective organization skills and ability to work in a multi-tasking, fast-paced environment
    • Use skills of persuasion and diplomacy to resolve issues impacting studies
    • Goal oriented, highly self-motivated, and self-directing individual who enjoys working in different environments and multiple capacities
    • Ability to work well in a team setting/matrix-type organization and to build strong cross-functional relationships
    • Enthusiasm for meeting program timelines and goals

    Upload Résumé (We prefer PDF format)

  • Scientist, RNAi Discovery

    Posted September 19, 2018

     

    Dicerna Phamaceuticals is looking for a PhD scientist to help in its drug discovery efforts.  This is a hands-on research position that requires strong expertise in molecular and cellular methodologies. This is a full-time position. Dicerna offers an exciting work environment and strong team culture. Our company has a competitive benefits package and bonus incentive program.

    Key Responsibilities

    • siRNA drug candidate screening, hit identification, and lead optimization
    • Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; PCR
    • In vivo drug candidate testing (e.g. mouse dosing; sample analysis)

    Qualifications

    • PhD in a relevant field and 0-5 year’s postgraduate experience, preferably in drug discovery and in an industry setting
    • Expertise in cellular and molecular biology is essential (e.g., mammalian cell culture; cell-based assays; quantitative real-time PCR)
    • Experience with RNAi is preferred
    • Experience with in vivo methodologies is desirable (e.g. mouse handling; dosing; sample analysis; histology)
    • The individual should have strong oral and written communication skills and a demonstrated ability to contribute effectively to group projects in a team-oriented environment
    • Ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected

    Upload Résumé (We prefer PDF format)

  • Associate Director, Clinical Quality Assurance

    Posted October 18, 2018

     

    We are seeking an Associate Director, Clinical Quality Assurance to manage the ongoing Clinical QA activities to support GCP and Clinical Trial Obligations.  You will support clinical development and be empowered to develop clinical quality programs and systems as you represent Clinical QA.

     

    Responsibilities

    • Collaborate with Clinical Development and related functional areas to ensure clinical trial activities are conducted in compliance with Good Clinical Practice (GCP) regulations, the International Conference on Harmonization (ICH) and Dicerna Policies and Procedures.
    • Interpret and provide key metrics to Clinical Development Team, Quality Team and cross-functional development team members.
    • Support GCP SOP development and serve as quality operations reviewer. Act as a strategic GCP quality resource providing GCP technical guidance recommendations to development teams.
    • Execute risk-based methodologies for the planning and execution of clinical protocols
    • Manage clinical quality issues including audit reports, quality issues/incidents, and CAPA development.  Ensure timely implementation and closure of CAPAs.
    • Facilitate the assessment and investigation of quality issues, by driving root cause analysis and remediation. Ensure timely review and closure of quality issues.
    • Lead systems monitoring and process improvement initiatives that enhance regulatory compliance and CQA operating efficiency.
    • Assist with inspection readiness including SME training/preparation and back room activities during GCP inspections.  Analyze the risks, propose the strategy for readiness and manage the implementation of readiness program.
    • Use knowledge of GCP, clinical development, and industry best practices to provide guidance, training and input to business partners on compliance issues. Able to adapt precedent and develop creative and effective solutions to solve problems.

    Qualifications

    • BSN or B.S. in related scientific field is required.
    • 8+ years of experience in the pharmaceutical or biotechnology industry with 5 years of GCP-related Quality Assurance experience.
    • In depth knowledge of the applicable global GCP regulations, Good Clinical Practices, ICH Guidelines.
    • Advanced knowledge in the conduct and reporting of audits and the translation of findings into corrective actions plans that mitigate risks to the company, to safety and to data integrity.
    • Strong organizational and management skills to communicate to multi-disciplinary project teams.
    • Ability to present data and defend approaches to inspectors.
    • Ability to comprehend regulations and guidance documents and technical information related to equipment, processes, and regulatory expectations.
    • The ability to think strategically and maintain an attention to detail.
    • Capable of working independently with minimal supervision and interacting with staff in a fast-paced sometimes pressure filled environment.
    • Excellent written and verbal communication skills coupled with strong negotiation and decision-making skills.
    • Strong comprehension of while applying critical thinking skills to evaluate requirements.

     

    Upload Résumé (We prefer PDF format)

  • Medicinal Chemist

    Posted November 2, 2018

     

    We are seeking a highly skilled and motivated synthetic chemist able to function in a fast-paced, collaborative environment. The successful candidate will be a member of the chemistry team responsible for the synthesis of nucleoside analogues and oligonucleotide conjugates and will work closely with contract research/manufacturing organizations on the scale-up and tech transfer of processes.

     

    Responsibilities

    •Design, plan and execute multi-step organic synthesis and purification of high quality target molecules.

    •Review research papers and intellectual property literature and propose novel target molecules.

    •Operate and maintain multiple instrumentation including HPLC, LCMS for purification, characterization and purity determination of prepared compounds.

    •Assist in the planning and management of external research efforts for contract research organizations and collaborations.

    •Function as a senior member of the chemistry group aiding in the preparation of intellectual property, publications, and project planning.

    Qualifications

    •Ph.D. in organic chemistry with 1-7 years of relevant experience.

    •In-depth knowledge of organic chemistry reactions and mechanisms.

    •Experience with chromatography techniques i.e. LC-MS, ion exchange and RP-HPLC.

    •Thorough understanding of analytical techniques (HPLC, LC-MS) for characterization of nucleoside and oligonucleotide compounds.

    •Ability to work independently and collaboratively in a fast-paced, matrixed, team environment consisting of internal and external team members.

    •Experience in heterocyclic and/or carbohydrate chemistry, familiarity with nucleoside synthesis, bio conjugate chemistry is preferred along with knowledge in oligonucleotide chemistry.

    Upload Résumé (We prefer PDF format)

  • Scientist/Associate Scientist/Research Associate – Oligonucleotide Synthesis

    Posted November 2, 2018

     

    Dicerna Pharmaceuticals is seeking highly motivated scientists to join its oligonucleotide/medicinal chemistry team in Cambridge, Massachusetts. The candidates will be responsible for the synthesis, deprotection, and purification of oligonucleotides, and the analysis and characterization of oligonucleotides. This position will support therapeutic programs in multiple disease areas and will contribute to the development of novel nucleic acid conjugate platforms. Prior experience in oligonucleotide synthesis and characterization is desired but not required.

     

    Key Responsibilities:

    • Synthesis of oligonucleotides, deprotection, purification, annealing and lyophilization of oligonucleotides to support all disease programs
    • Analytical characterization of the synthesized oligonucleotides for purity determination and impurity profiling
    • Support new chemistry discovery for the development of novel oligonucleotide conjugate platforms
    • Operate, maintain, and troubleshoot lab instruments such as oligonucleotide synthesizers, purification systems, HPLC and LC-MS
    • Conduct laboratory work in safe, efficient manner that ensures a safe working environment for colleagues
    • Ability to complete assignments and meet deadlines and time schedules
    • Keep accurate record of the experiments and summarize the results in written reports
    • Possess excellent written and verbal communication skills
    • Demonstrate an ability to work as part of a team and possess an excellent work ethic
    • Ability to be successful in a fast-paced, intense work environment

    Qualifications:

    • PhD in Chemistry or related field with 1-2 years of industrial experience, or MS with at least 3 years of industrial experience, or BS with 5 Years
    • Strong knowledge of nucleic acids chemistry, oligonucleotide synthesis, deprotection and purification techniques
    • Experience with oligonucleotide synthesizers preferred
    • Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation

    Upload Résumé (We prefer PDF format)

  • Senior Medical Writer

    Posted November 28, 2018

     

    The medical writer will be a key member of the Project Team and will work closely with Research, Clinical Operations and Regulatory Affairs to manage all aspects of document preparation for clinical and regulatory documents according to company guidelines and international governmental regulations.  S/he will provide strategic direction to cross-functional teams to ensure that key messages are consistently aligned with reporting requirements and company objectives.

     

    Key Responsibilities: 

    • Plan, prepare, write, edit, format, and finalize non-clinical, clinical, CMC and regulatory documents. Documents will include, but are not limited to: IND, CTA, non-clinical summaries, clinical protocols, clinical study reports, Investigator brochures, updates to regulatory submissions, annual reports/development safety update reports (DSURs), IMPDs etc.
    • Assist in developing strategy for organizing and preparing documents for regulatory health authority submissions.
    • Coordinate the internal review of documents.
    • Develop, maintain, and drive document finalization timelines.
    • Ensure final document adheres to standard operating procedures (SOP), good clinical practice (GCP), and the International Council on Harmonisation (ICH).
    • Perform quality control review of medical writing documents
    • Assist in the development of templates, style guidelines, and SOPs for clinical documentation

    Qualifications:

    • Minimum requirement of a bachelor’s degree with 8+ years of medical writing experience in a pharmaceutical/biotechnology or CRO environment
    • Ability to interpret and present clinical and non-clinical data objectively in a clear, concise format.
    • Outstanding written and oral communication skills
    • Proficiency in teamwork, organization, and project management
    • Proficiency in MS Office; experience using electronic document management system

    Upload Résumé (We prefer PDF format)

  • Senior Associate, Financial Reporting

    Posted November 29, 2018

     

    Due to the Company’s rapid growth, we have a need to expand our Finance team.  We are now seeking a Financial Reporting Senior Associate or Manager to play an important role in the Company’s financial reporting, technical accounting, tax compliance, and internal control activities. This position is a newly created role.

     

    Key Responsibilities

    ·         Play a key role in the preparation of filings with the SEC including 10-Qs, 10-Ks, 8-Ks, and Proxy statements.

    ·         Complete tie-outs for all financial regulatory filings with a focus on excellence and creating a model for others of documentation best practices, particularly as it relates to SOX.

    ·         Complete quarterly and annual disclosure checklists.

    ·         Serve as the key liaison between the accounting team and other control owners as it pertains to ongoing SOX compliance, including periodic risk assessments and coordination of independent controls testing.

    ·         Research, monitor, and ensure timely identification and compliance with evolving accounting guidance.

    ·         Prepare technical accounting memos to document analysis and conclusions in the application of accounting guidance for non-routine transactions or the implementation of new accounting standards.

    ·         Participate in the research and collection of data, as well as consultation with external advisors and auditors in the implementation of new guidance.

    ·         Draft and review accounting policies.

    ·         Assist in various tax compliance and related initiatives.

    ·         Special projects as assigned by the Director of Financial Reporting

    Qualifications

    ·         Bachelor’s or Master’s degree in Accounting

    ·         4+  years of public accounting experience with a large national firm or a mix of public/private experience

    ·         Certified Public Accountant designation preferred

    ·         Biotech experience highly desirable       

    ·         Strong attention to detail

    ·         Excellent written and verbal communication skills

    ·         Familiarity with SOX implementation and compliance

    ·         Comfort with and skill in performing technical accounting research

    ·         Ability to manage various tasks and appropriately re-prioritize as necessary to meet business needs

    ·         Exceptional work ethic and unquestionable integrity

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  • Toxicology Study Manager

    Posted November 29, 2018

     

    We are seeking a Toxicology Study Manager to help advance the development of our growing pipeline of product candidates.  The individual in this position will assist in the oversight of toxicology programs by serving as the Sponsor Representative for studies conducted at external contract research organizations (CRO).

    Key Responsibilities

    • Responsible for management, operational oversight, and may be involved with on-site monitoring of toxicology studies conducted at CROs
    • Serve as the point person for managing study communications, activities, and documents from Request for Proposal (RFP) to study closure. This includes keeping team electronic file storage sites up to date.
    • In partnership with the Study Monitor/Toxicologist, contribute to study designs, protocol development, and written reports. Draft CTD tables from study data.
    • Facilitate review and compilation of feedback from stakeholders for study related documentation. Provide QC of tables and reports as needed.
    • Work closely with CROs to ensure that all studies are performed in a high quality and timely manner in order to meet program goals
    • Facilitate study-related shipments and data transfer
    • May participate in CRO evaluation and qualification
    • May contribute to the preparation of nonclinical components for regulatory submissions
    • Collaborate cross functionally with Research, Regulatory, Clinical, and Manufacturing and relevant program teams
    • Communicate toxicology timelines and data to stakeholders as needed
    • Some travel (domestic and international) will be required depending on project needs

    Qualifications

    • B.S. in a scientific discipline, toxicology-related discipline preferred, with 3-5 years of pharmaceutical industry or CRO experience
    • Experience with oligonucleotides preferred but not required
    • Knowledge of global regulatory guidances (e.g. ICH and geography-specific) and Good Laboratory Practice (GLP) standards
    • With attention to detail, ability to critically evaluate all study documentation (eg. protocols, data, reports)
    • Ability to determine test article needs and calculate or confirm dosing solution calculations
    • Effective organization skills and ability to work in a multi-tasking, fast-paced environment
    • Use skills of persuasion and diplomacy to resolve issues impacting studies
    • Goal oriented, highly self-motivated and self-directing individual who enjoys working in different environments and multiple capacities
    • Ability to work well in a team setting/matrix-type organization and to build strong cross-functional relationships
    • Enthusiasm for meeting program timelines and goals

     

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  • Senior Research Associate – Translational Biology

    Posted December 4, 2018

     

    We are seeking a highly skilled senior research associate to lead mechanism of action and pharmacology studies on Dicerna’s GalXC therapeutics. Major responsibilities include conducting in vivo studies on our pre-clinical and clinical candidates and conducting hands-on research. You will apply your expertise in working with animal models and deep understanding of the molecular and cellular biology to support all phases of drug discovery and clinical development at Dicerna.

     

    Key Responsibilities

    • Play a role in guiding creative and rigorous biological research programs aimed at fully understanding the disease mechanism of Dicerna’s pipeline and directly contribute to the success of Dicerna’s strategic collaborations.
    • Conduct efficacy, pharmacokinetic, pharmacodynamics, structure-activity-relationship and mechanisms of action studies of drug candidates
    • Use appropriate in vivo models to understand the mechanisms by which our drug candidates may contribute to efficacy and potential adverse events in patients
    • Present working progress to team members in group meeting
    • Work closely with members of Dicerna’s research team to develop molecular and cellular assays to quickly and effectively address key questions related to the safety and efficacy of our drugs.
    • Review literature and provide insights to research directions, while predominantly making hands-on contributions to the research

    Qualifications

    • Bachelor’s or Master’s Degree in Biology, Pharmacology, or related field, with a minimum of 5-10 years of experience.
    • Proficiency in animal handling and dosing is required. Experience with small animal surgery preferred. Proficient in techniques including but not limited to oral gavage, intravenous injection, subcutaneous injection, blood collection and basic surgery
    • In depth knowledge of, and hands-on experience with, in vitro and in vivo models used for mechanistic investigation with small molecule or RNAi therapeutics
    • Experience performing molecular and cellular biology techniques, including but not limited to RNA preparation, RT-qPCR, ELISA, immunohistochemistry, western blot
    • Previous experience in drug discovery is preferred
    • Outstanding written and oral communication skills
    • A high level of motivation and demonstrated record of accomplishment throughout your career
    • The ability to work effectively as part of a team, in a fast-paced environment

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  • Scientist, Translational Biology

    Posted December 5, 2018

     

    We are seeking a highly skilled scientist to play a prominent role in guiding creative and rigorous biological research programs aimed at fully understanding the disease mechanism of Dicerna’s pipeline. This individual will apply his/her expertise and deep understanding of molecular and cellular biology to study liver diseases and play a key role in all phases of drug discovery and clinical development at Dicerna.

     

    Key Responsibilities

    • Investigate liver diseases to lead mechanism of action and pharmacology studies on Dicerna’s GalXC therapeutics and directly contribute to the success of Dicerna’s strategic collaborations.
    • Design and manage in vivo animal models of disease to evaluate the efficacy, pharmacodynamics, and mechanisms of action of pre-clinical and clinical drug candidates.
    • Lead internal and external research efforts to understand the mechanisms by which our drug candidates may contribute to adverse events in patients and evaluate therapeutic hypotheses.
    • Prepare high quality technical reports and summaries for internal use and inclusion in key regulatory documents (e.g. INDs and NDAs).
    • Work closely with internal research team, external collaborators, and contract research organizations (CROs) to develop in vivo strategies to rapidly and effectively address key questions related to the safety and efficacy of our drugs, with actionable results.
    • Review literature and provide insights to research directions, while also making hands-on contributions to the research.
    • Regularly present work progress to rest of company.

    Qualifications

    • PhD in Biology, Pharmacology, biochemistry, molecular biology or related field, with 0-5 years of industry experience
    • Broad and deep understanding of signaling pathways and biological processes implicated in genetic diseases, and the mechanisms of action of RNAi therapies is preferred
    • In depth knowledge of, and hands-on experience with, in vitro and in vivo models used for mechanistic investigation of liver biology and toxicity, and identification of biomarkers
    • Experience performing molecular and cellular biology techniques including but not limited to RNA preparation, RT-qPCR, ELISA, immunohistochemistry, and western blot
    • Demonstrated record of accomplishment throughout your career
    • Strong publication record
    • Outstanding written and oral communication skills
    • The ability to work effectively as part of a team, in a fast-paced environment
    • Experience managing more junior staff is desirable

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  • Research Associate/Associate Scientist, RNAi Pharmacology

    Posted December 6, 2018

     

    Dicerna is a rapidly growing biopharmaceutical company focused on the discovery and development of innovative therapeutics for rare diseases, chronic liver diseases, cardiovascular disease, and infectious diseases.  The Company is using its proprietary GalXC™ RNAi technology platform to build a broad pipeline in these therapeutic areas.  Dicerna offers a unique and exceptional culture that thrives on energy, sharing of ideas and overall excellence.  We believe in career development and enhancing the work environment with industry-leading perks (daily catered lunches, fun corporate outings, community volunteering opportunities).  We offer competitive salaries and excellent benefits.

     

    Key Responsibilities

    • Rodent dosing, sampling and necropsy; planning and performing of all technical aspects of in vivo experiments; contributing to experimental design and strategy
    • Cross-functional collaboration to help enable efficient operation of our on-site animal care facility (ACF)
    • Performing laboratory assays according to SOPs, troubleshooting as needed; assay development. Generating data using both standard and novel molecular technologies
    • Maintaining careful laboratory notebooks and generating high quality study reports
    • Contributing to a team tasked with evaluating novel experimental medicines in preclinical models of disease, and advancing our technology to enable development of the next generation of innovative RNA-based therapeutics

    Qualifications

    • BS or MS in Biology, Pharmacology, Biochemistry, Pharmaceutical Sciences or equivalent
    • 1+ years (Research Associate) or 5+ years (Associate Scientist) of experience in a relevant industrial or academic setting
    • Experience in rodent pharmacology including dosing, tissue collection and study management and study documentation
    • Experience in standard laboratory methodologies; aseptic technique; working knowledge of molecular biology.  Examples include qPCR, immunohistochemistry, ELISA/Western, FACS
    • Experience in data analysis methods, including scientific software
    • Commitment to careful and thorough technical documentation, including electronic laboratory notebooks and study reports
    • Ability to interact effectively on multidisciplinary teams and participate in our exciting, dynamic company culture; ability to work independently
    • Ability to multitask and prioritize

     

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  • Scientist/Senior Scientist, RNAi Pharmacology

    Posted December 6, 2018

     

    Dicerna is a rapidly growing biopharmaceutical company focused on the discovery and development of innovative treatments for rare diseases, chronic liver diseases, cardiovascular and infectious diseases.  The Company is using its proprietary GalXC™ RNAi technology platform to build a broad pipeline in these therapeutic areas.  Dicerna offers a unique and exceptional culture that thrives on energy, sharing of ideas and overall excellence.  We believe in career development and enhancing the work environment with industry-leading perks (daily catered lunches, fun corporate outings, community volunteering opportunities).  We offer competitive salaries and excellent benefits.

     

     Key Responsibilities

    • Project leadership: perform innovative and challenging science to meet milestones
    • Pharmacodynamic and pharmacokinetic characterization of novel experimental RNAi therapeutics in rodents, and generation of molecular endpoint data
    • Development or implementation of rodent disease/phenotypic models to achieve therapeutic proof-of-concept
    • Collaboration with discovery biologists and medicinal chemists for technology development and lead optimization; interface with external partners
    • Pharmacology support for nonclinical and clinical-stage pipeline programs
    • Generation and communication of high quality study reports, data packages, SOPs and related documentation

    Qualifications

    • Ph.D. or equivalent in Biology, Pharmacology, Biochemistry, Pharmaceutical Sciences or a related discipline
    • Expertise in rodent pharmacology including study design, dosing, necropsy, tissue processing; strong molecular biology and assay development/implementation skills (examples, but not all necessarily required: qPCR, NGS, FACS, Western/ELISA, IHC/histology); experience in sophisticated disease modeling strategies.  Working knowledge of drug discovery processes, SAR and PK/PD concepts
    • A range of postgraduate experiences will be considered, both in terms of time (3-15 years) and setting (industry or academia)
    • Demonstrated scientific track record is required
    • Experience in, or working knowledge of, nucleic acid therapeutics is a significant plus
    • Experience in chronic liver or cardiometabolic metabolic diseases is a plus
    • Commitment to scientific rigor, high data quality and careful documentation
    • Ability to interact effectively on multidisciplinary teams and participate in our exciting, dynamic company culture
    • Ability to multitask, prioritize and manage timelines, manage projects and/or people
    • Strong scientific writing skills, and experience in delivering effective scientific presentations to internal or external teams

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  • Accounting Manager

    Posted December 7, 2018

     

    Job Summary:

    The Accounting Manager serves a critical role in ensuring the accurate and timely preparation and recording of monthly entries and complete all required reporting.

     

    Key Responsibilities:

    ·         Plays a key role in the close process, including preparation of general ledger entries, account reconciliations, and detailed account analysis.

    ·         Develop and maintain models for R&D and Manufacturing activities by working with the operational teams, reviewing contracts and reviewing general ledger activity.  Book necessary entries and complete all necessary reporting.

    ·         Create reporting and tracking for partnerships.

    ·         Responsible for all grant accounting, partnership revenue and lease accounting and all associated reporting

    ·         Partner with Technical accounting to book revenue appropriately and update schedules as needed.

    ·         Lead equity administration and stock-based compensation accounting.

    ·         Maintain and monitor internal controls to ensure Sarbanes-Oxley (SOX) compliance and provide support for Sarbanes-Oxley testing.

    ·         Assist with special projects as needed.

    Qualifications:

    ·         A Bachelor’s Degree in Accounting.

    ·         Five (5) to seven (7) years of applicable experience, public accounting experience a plus

    ·         Knowledge of U.S. GAAP.

    ·         Clinical and industry experience a plus.

    ·         Familiarity with grant accounting.

    ·         Excellent communication skills, both written and verbal with the ability to work with all levels of management and employees.

    ·         Knowledge of Great Plains and Certent.

    ·         Excellent Excel and other Microsoft Office application skills.

    ·         Extremely well-organized and goal oriented with the ability to deliver results on time.

    ·         Willingness to be responsible for and perform tasks over a relatively wide spectrum; “roll-up-your-sleeves” attitude with a desire to advance career-wise.

    ·         Exceptional work ethic and unquestionable integrity.

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  • VP Business Development

    Posted December 12, 2018

     

    Reporting to the Chief Business Officer, the Vice President of Business Development will be a key member of the company’s executive team with a high degree of visibility and impact across the organization.  The VP of BD will bring a strong strategic mindset and a proven track record of business development experiences which can be applied to future deals and alliances.  Responsibilities include oversight of all corporate development strategy including evaluation of opportunities, maintaining and building strong relationships and credibility with strategic partners, conducting/organizing due diligence, and execution of strategic deals and partnerships.

     

    It is anticipated that this executive will have the ability to be a high-profile external representative of the company in business development settings. Dicerna will undergo significant growth in the upcoming years and the VP of BD will need the skills to work effectively in a dynamic, cross-functional organization. The ability to scale and influence within fast moving, high growth organizations will be essential.

     

    Key Responsibilities

    • Serve as a key member of the executive team in the continuing development and execution of Dicerna’s corporate and business development strategy. The VP of BD will articulate and execute the strategy.
    • Manage the day-to-day corporate and business development activities, lead internal team to identify and develop opportunities of highest interest/value, organize diligence activities, partner with external counsel, and lead negotiations.
    • Collaborate with senior management of potential partners and/or target organizations; communicate in a manner that reflects positively on the company, its’ strategy and core values.
    • Oversee the development of financial analysis and valuation models for potential corporate collaborations and partnerships, working closely with the Finance and Development teams.
    • Collaborate with the Alliance Management function to support key current partnerships and scale to support future partnerships.
    • Ensure that the company maintains a strong presence at key business development forums.

    Qualifications

    • A minimum of 10 years (bio)pharmaceutical industry experience including leadership experience across business development, licensing and strategic planning.
    • Direct involvement and experience on both the “sell” and “buy” sides of strategic partnerships, alliances, and in-licensing/out-licensing arrangements.
    • Creative thinking with the ability to translate corporate development goals into a business development strategy with appropriate tactics.
    • Wide experience in all aspects of business development and licensing including evaluation, due diligence, modeling, negotiating, and closing deals.
    • A strong understanding of drug development and commercialization.
    • Experience working cross-functionally with R&D, finance, legal, human resources and commercial organizations, to formulate business development strategy and drive competitive initiatives to successful conclusions.
    • The ability to move within a fast-paced environment is critical to success in this role.
    • Excellent communicator and influencer with effective presentation skills.
    • Bachelor’s Degree required; M.B.A. and/or other advanced degree preferred.

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