Careers

Careers

At Dicerna, we foster a culture of innovation through collaboration.

View our list of career opportunities.

 

We are dedicated to benefiting patients by advancing science and developing creative solutions to challenging therapeutic problems. Our core values of dedication, innovation, communication, excellence, respect, needs based and accountability drive us personally and as a team, and these are critical factors in the long-term success of our company.

We encourage open dialogue to identify and act upon novel ideas to meet the urgent needs of patients.

As innovators in the emerging area of RNAi, we seek forward-thinking talent to join our growing team, advance our robust pipeline of therapies, and provide ground-breaking medicines to those that depend on us.

Our office location in Cambridge underscores our commitment to being an employer of choice in the Massachusetts life sciences sector, and to being in close proximity to world-class research, academic and healthcare institutions as well as other life sciences leaders. We play an active role in the biotechnology community and in the Alewife business community as the area undergoes a revitalization to become a mini life sciences and technology hub. Our office is close to the MBTA subway and buses, the 120-acre Alewife Reservation, as well as many restaurants and services.

 

Dicerna is proud to be an Equal Opportunity Employer.

For interest in future employment opportunities, please submit your resume to Megan Garrapy at mgarrapy@dicerna.com.

 

Career Opportunities

  • Toxicologist

    Posted August 11, 2017

     

    We are seeking a Toxicologist to help advance the development of our growing pipeline of product candidates.  The individual in this position will participate on program development teams, and assist in the design and oversight of toxicology studies and preparation of regulatory submissions.

    Key Responsibilities

    • In conjunction with program teams, design and oversee conduct of external non-GLP investigative or GLP toxicology studies to support novel therapeutic agents through the drug development process
    • Serve as Study Monitor/Sponsor Representative for outsourced toxicology studies.  Review and provide feedback on related study protocols and reports
    • Contribute to the preparation of nonclinical components for regulatory submissions.
    • Collaborate on design of internal non-GLP investigative toxicity studies in support of development compounds as needed
    • Collaborate cross functionally with Research, Regulatory, Clinical and Manufacturing
    • Communicate toxicology data to Dicerna program teams and executive leadership as required

    Qualifications

    • Ph.D in a scientific discipline, toxicology related discipline preferred, with 5-10 years of pharmaceutical industry experience as a toxicologist
    • Experience with oligonucleotides preferred
    • Knowledge of global regulatory guidances (e.g. ICH and geography-specific) and Good Laboratory Practice (GLP) standards
    • Ability to critically evaluate written toxicology documents for overall quality and acceptability of scientific interpretation
    • Experience in developing toxicology programs to support early and later stage drug development and in preparing regulatory filings such as INDs/CTAs preferable
    • Effective organization skills and ability to work in a multi-tasking, fast-paced environment
    • Ability to work well in a team setting/matrix-type organization and to build strong cross-functional relationships
    • Some travel (domestic and international) will be required depending on project needs

    *** The right candidate will be considered for location in Cambridge, MA or Boulder, CO (area)

    Upload Résumé (We prefer PDF format)

  • Research Associate/ Sr. Research Associate

    Posted May 7, 2018

     

    Job Description:

    We are seeking a highly motivated and scientifically rigorous individual to join our research team as a Research Associate / Senior Research Associate.

    Key Responsibilities

    • Test in vitro and in vivo activity of drug candidates
    • Develop and perform molecular and biological assays
    • Maintain cell cultures and perform cell-based assays and cell-free assays.
    • Techniques include: Cell culture (cell lines and primary cells); qPCR; western blotting; ELISAs; enzymatic assays; absorbance and fluorescence spectrometry; mouse handling and dosing.
    • Effectively communicate results of experiments to project teams.
    • Maintain good written records of experiments, protocols and procedures.

    Qualifications

    • BS/MS in a relevant field with at least 2 years of academic or industry experience
    • Expertise in cellular and molecular biology is essential, specifically mammalian cell culture; cell-based assays; quantitative PCR; western blotting;
    • Experience with animal work (e.g. mouse handling) is required; experience with in vivo methodologies is desired, e.g. dosing; tissue sampling; disease modeling; histology
    • Experience with RNAi is preferable
    • Familiarity with bioinformatics tools and databases is preferred
    • Strong verbal and written communications skills
    • Demonstrated ability to work as a team player in a dynamic environment.

    Upload Résumé (We prefer PDF format)

  • Bioanalytical Chemist

    Posted March 6, 2018

     

    Overview 

    Dicerna is seeking an experienced Bioanalytical Chemist specializing in solving challenges in the analysis of molecular biomarkers and metabolites with a range of techniques and equipment. Experience in the bioanalysis and quantitation of oligonucleotides in biological matrices is a plus but is not required if balanced by a demonstrated breadth of bioanalytical experience. 

    Key Responsibilities 

    • Method development and quantitation of oligonucleotides in biological matrices including plasma, liver, and urine.
    • Operation and hands-on troubleshooting of multiple types of analytical instrumentation including HPLC, UPLC and LC-MS instruments.  
    • Method development for biomarker analysis.
    • Assist in the planning and management of contract research organizations and collaborations for the outsourcing of oligonucleotide bioanalysis. 
    • Technical support to non-clinical and clinical development activities including drafting and reviewing study reports for IND and CTA.

    Qualifications 

    • Ph.D. in Analytical Chemistry, Chemistry or Biochemistry with at least 3 to 5 years of relevant industrial experience in DMPK, biomarker and metabolite identification. 
    • Proficiency in mass spectrometry for metabolite profiling and identification.  
    • Experience with multiple types of analytical and chromatographic separation techniques, i.e. RP-HPLC, HILIC, SAEX and SEC. 
    • Strong computer skills and experience with software driven metabolite profiling is required. 
    • The successful candidate must be a resourceful and proactive individual who is able to work as a team player in a dynamic environment with tight deadlines. 

    Upload Résumé (We prefer PDF format)

  • Staff Accountant

    Posted April 9, 2018

     

    Overview

    Dicerna Pharmaceuticals, Inc. (the “Company”) is a biopharmaceutical company focused on the discovery and development of innovative treatments for rare diseases, chronic liver diseases, cardiovascular disease, and viral liver infectious diseases.  The Company is using its proprietary GalXC™ RNAi technology platform to build a broad pipeline in these therapeutic areas.

    We are seeking a hands-on Staff Accountant who will report to the Company’s Assistant Controller and be responsible for a variety of accounting and finance activities.

    Key Responsibilities

    • Maintain daily cash transactions log and compile transaction support for banking entry postings.
    • Maintain fixed assets and depreciation schedules and assist with implementation of the fixed assets module in the Company’s enterprise resource planning (“ERP”) system.
    • Maintain prepaid and amortization schedules and documentation.
    • Prepare other routine monthly general journal entries, related support and maintain schedules.
    • Assist in managing the Company’s time tracking application, including for government grants.
    • Assist in monthly/quarterly/annual close process, including preparing account reconciliations, support schedules and other analyses and assist in preparing the monthly close support binder.
    • Help provide information and support in connection with the Company’s annual tax return filing process.
    • Support Company-wide procurement initiatives, including administration of purchasing requisition system.
    • Assist with implementing, maintaining and adhering to internal controls as they relate to relevant functions for Sarbanes-Oxley compliance.
    • Assist with accounting/finance process improvements and other projects/analyses as required.

    Required Skills and Experience

    • Bachelor’s Degree in Accounting with a minimum of two to three years of accounting experience preferably in a publicly traded, growth-oriented biopharmaceutical company.
    • Proficiency with Great Plains ERP, including fixed asset module.
    • Strong proficiency with Excel and other Microsoft Office applications.
    • Excellent communication, organizational and interpersonal skills.
    • Goal oriented and proven ability to deliver results on time.
    • Willingness to “roll up your sleeves” and get heavily involved in transaction details.
    • Outstanding work ethic and unquestionable integrity.
    • Knowledge of Certent, ReQlogic and Concur a plus.

    Upload Résumé (We prefer PDF format)

  • Senior/Director of Financial Reporting

    Posted May 1, 2018

     

    Overview

    Dicerna is a biopharmaceutical company focused on the discovery and development of innovative treatments for rare diseases, chronic liver diseases, cardiovascular disease, and viral liver infectious diseases.  The Company is using its proprietary GalXC™ RNAi technology platform to build a broad pipeline in these therapeutic areas.

    We are seeking a Senior/ Director of Financial Reporting to manage the Company’s internal and external financial reporting, tax, policy development and internal control environment.

    Key Responsibilities

    • Prepare quarterly and annual filings with regulatory authorities (i.e. Securities and Exchange Commission (“SEC”)).
    • Prepare annual proxy statements and other SEC filings, such as 8-Ks and earnings release support and S-8s; be a key contributor to preparing filings associated with financing activities (i.e. S-3s).
    • Design and maintain internal controls over financial reporting in accordance with the relevant sections of the Sarbanes Oxley Act (“SOX”).
    • Manage ongoing SOX compliance, including periodic risk assessments and coordination of independent controls testing.
    • Perform technical accounting research and conclude and report on generally accepted accounting principles (“GAAP”)-compliant accounting treatment following the issuance of new accounting pronouncements and in connection with non-routine transactions and arrangements and in connection with business development initiatives.
    • Act as a key point of contact with the Company’s external auditors during quarterly reviews and annual audits.
    • Prepare periodic internal reports for distribution to the Company’s Board of Directors and other groups as needed.
    • Collaborate with the Company’s Senior Director of Financial Planning and Analysis as needed to support budget and forecasting initiatives and related reporting.
    • Manage tax compliance and related initiatives (including tax return preparation, transfer pricing, deferred taxation and financial statement disclosures).
    • Establish positive working relationships with non-finance department staff in order to identify and address all areas with financial reporting implications.

    Qualifications

    • Minimum of ten years of experience, including “Big Four” audit and several years of post-audit experience in a similar role within a publicly traded, development-stage, growth-oriented biopharmaceutical organization.
    • Certified Public Accountant designation required (active license).
    • Demonstrated ability to lead all SOX control design and compliance matters.
    • Strong technical skills and ability to analyze complex accounting transactions, perform GAAP research and prepare whitepapers/memoranda that are “audit-ready” in areas including, but not limited to, revenue recognition and equity accounting.
    • Strong interpersonal skills and an ability to work in a cross-functional, team-oriented environment.
    • Excellent written and verbal communication skills. Adept at presenting information and conclusions professionally, clearly and concisely.
    • Proficiency with Great Plains ERP and report writing functionality a plus.
    • Goal oriented, with the ability to proactively provide solutions to ensure that all key initiatives are carried out in accordance with pre-established deadlines.
    • Exceptional work ethic and unquestionable integrity.

    Upload Résumé (We prefer PDF format)

  • Receptionist

    Posted May 2, 2018

     

    General Job Responsibilities:

     

    • Provide administrative support to the Dicerna team, Sr. Executive Assistant and other senior executives, including meeting scheduling as needed, preparing expense reports, travel planning, coordinating onsite meetings and other tasks associated with supporting a very busy office.
    • Greet visitors and reserve meeting rooms
    • Oversee and manage Dicerna facility’s needs, including general maintenance and upkeep, receiving/shipping, and dealing with other issues as needed
    • Order office supplies, stock kitchen items, manage catering needs for daily lunches,
    • Interact with vendors & negotiate contracts on behalf of Dicerna including IT, telecommunications, stationary, catering, office/labs supplies
    • Maintain vendor lists, seating charts, employee lists, journal of scientific library, etc.
    • Streamline procedures and policies
    • Work with accounting department to match shipping labels & POs to invoices.
    • Mailings via US mail, Fed Ex, UPS, etc.
    • Help coordinate company events and communications and special gifts, etc., that enhance and enliven the corporate culture and work environment

     

    Looking for a positive, energetic individual to work in a fast-paced, growing company.  Must be a self-starter and possess an ability to multitask – wearing multiple hats at any given time.  Must have at least 3-5 years of administrative experience, preferably in the Bio/Pharma industry.

    Upload Résumé (We prefer PDF format)