Careers

Careers

At Dicerna, we foster a culture of innovation through collaboration.

View our list of career opportunities.

 

We are dedicated to benefiting patients by advancing science and developing creative solutions to challenging therapeutic problems. Our core values of dedication, innovation, communication, excellence, respect, needs based and accountability drive us personally and as a team, and these are critical factors in the long-term success of our company.

We encourage open dialogue to identify and act upon novel ideas to meet the urgent needs of patients.

As innovators in the emerging area of RNAi, we seek forward-thinking talent to join our growing team, advance our robust pipeline of therapies, and provide ground-breaking medicines to those that depend on us.

Our office location in Cambridge underscores our commitment to being an employer of choice in the Massachusetts life sciences sector, and to being in close proximity to world-class research, academic and healthcare institutions as well as other life sciences leaders. We play an active role in the biotechnology community and in the Alewife business community as the area undergoes a revitalization to become a mini life sciences and technology hub. Our office is close to the MBTA subway and buses, the 120-acre Alewife Reservation, as well as many restaurants and services.

 

Dicerna is proud to be an Equal Opportunity Employer.

For interest in future employment opportunities, please submit your resume to Megan Garrapy at mgarrapy@dicerna.com.

 

Career Opportunities

  • Toxicologist

    Posted July 11, 2018

     

    We are seeking a Toxicologist to help advance the development of our growing pipeline of product candidates.  The individual in this position will participate on program development teams, and assist in the design and oversight of toxicology studies and preparation of regulatory submissions.

    Key Responsibilities

    • In conjunction with program teams, design and oversee conduct of external non-GLP investigative or GLP toxicology studies to support novel therapeutic agents through the drug development process
    • Serve as Study Monitor/Sponsor Representative for outsourced toxicology studies.  Review and provide feedback on related study protocols and reports
    • Contribute to the preparation of nonclinical components for regulatory submissions.
    • Collaborate on design of internal non-GLP investigative toxicity studies in support of development compounds as needed
    • Collaborate cross functionally with Research, Regulatory, Clinical and Manufacturing
    • Communicate toxicology data to Dicerna program teams and executive leadership as required

    Qualifications

    • Ph.D in a scientific discipline, toxicology related discipline preferred, with 5-10 years of pharmaceutical industry experience as a toxicologist
    • Experience with oligonucleotides preferred
    • Knowledge of global regulatory guidances (e.g. ICH and geography-specific) and Good Laboratory Practice (GLP) standards
    • Ability to critically evaluate written toxicology documents for overall quality and acceptability of scientific interpretation
    • Experience in developing toxicology programs to support early and later stage drug development and in preparing regulatory filings such as INDs/CTAs preferable
    • Effective organization skills and ability to work in a multi-tasking, fast-paced environment
    • Ability to work well in a team setting/matrix-type organization and to build strong cross-functional relationships
    • Some travel (domestic and international) will be required depending on project needs

    *** The right candidate will be considered for location in Cambridge, MA or Boulder, CO (area)

    Upload Résumé (We prefer PDF format)

  • Bioanalytical Chemist

    Posted March 6, 2018

     

    Overview 

    Dicerna is seeking an experienced Bioanalytical Chemist specializing in solving challenges in the analysis of molecular biomarkers and metabolites with a range of techniques and equipment. Experience in the bioanalysis and quantitation of oligonucleotides in biological matrices is a plus but is not required if balanced by a demonstrated breadth of bioanalytical experience. 

    Key Responsibilities 

    • Method development and quantitation of oligonucleotides in biological matrices including plasma, liver, and urine.
    • Operation and hands-on troubleshooting of multiple types of analytical instrumentation including HPLC, UPLC and LC-MS instruments.  
    • Method development for biomarker analysis.
    • Assist in the planning and management of contract research organizations and collaborations for the outsourcing of oligonucleotide bioanalysis. 
    • Technical support to non-clinical and clinical development activities including drafting and reviewing study reports for IND and CTA.

    Qualifications 

    • Ph.D. in Analytical Chemistry, Chemistry or Biochemistry with at least 3 to 5 years of relevant industrial experience in DMPK, biomarker and metabolite identification. 
    • Proficiency in mass spectrometry for metabolite profiling and identification.  
    • Experience with multiple types of analytical and chromatographic separation techniques, i.e. RP-HPLC, HILIC, SAEX and SEC. 
    • Strong computer skills and experience with software driven metabolite profiling is required. 
    • The successful candidate must be a resourceful and proactive individual who is able to work as a team player in a dynamic environment with tight deadlines. 

    Upload Résumé (We prefer PDF format)

  • Validation Manager

    Posted June 21, 2018

     

    As the Validation Manager you will provide validation services and expertise in support of clinical/commercial drug substance and drug product manufacturing. You will work closely with cross functional teams to ensure SOPs/validation policies are in compliance with industry practice and regulatory requirements.

     

    Key Responsibilities

    • Responsible for the planning, execution, and lifecycle maintenance of validation programs. Work with QA, regulatory, manufacturing, and process/analytical development to determine documentation for validation programs through all phases of product/process development, technology transfer and ultimately commercial manufacturing.
    • Oversee the development, execution, and reporting of validation protocols.
    • Ensure that validation plans, protocols, and regulatory summaries are conducted within approved timelines.
    • Ensure that the analysis of related protocols and report writing validation data are scientifically sound to support the process & product quality specifications within schedule parameters.
    • Develop, review, and approve documentation relating to equipment, cleaning, and processes as well as other subject matter areas as needed.
    • Write validation protocols as well as write comprehensive final reports including resolution of discrepancies, when applicable.
    • Support the review and approval of engineering and process development reports and specifications.
    • Conduct and approve validation assessments and risk analyses for equipment / systems and processes.
    • Review validation protocols, reports, data, plans, change controls, deviations and CAPAs for activities performed at CMOs.
    • Work with multidisciplinary teams to address deviations as well as recommend and implement corrective and preventative actions.
    • Contribute to the development of new or improved validation practices by identifying more efficient approaches to typical practices or problem scenarios.
    • Communicate validation requirements, timelines, and resource needs to senior management.
    • Travel percentage 25%

     

    Qualifications

    • Bachelor’s or Master’s degree in an engineering or scientific discipline with a minimum of 10 years of industry experience in a validation/quality role in the life sciences regulated industry.
    • Experience working in a cGMP environment and knowledge of ICH Q8, Q9, Q10 and FDA, ISO and cGMP regulations.
    • Application of risk based approach to validation (FMEA, PHA, etc.).
    • Knowledge of Validation Lifecycle Approach, such as ASTM E-2500.
    • Ability to perform basic statistical analysis of validation test results.
    • Strong technical writing and verbal communication skills – Clearly conveys information and concepts/principles.
    • Thorough understanding of cGxP and applicable regulations, ability to interpret and apply regulations to complex issues to make risk management recommendations.
    • Ability to perform basic statistical analysis of validation test results.
    • Ability to multi-task and work in a fast paced and dynamic environment.
    • Experience overseeing contract manufacturers.

    Upload Résumé (We prefer PDF format)

  • Associate Director, Corporate Financial & Strategic Planning

    Posted June 28, 2018

     

    We are seeking an a creative, resourceful and critical thinker for our Corporate Financial & Strategic Planning team.  This individual will be joining a dynamic and collaborative Finance group reporting to the VP, Corporate Financial & Strategic Planning.  This key role will provide the opportunity to work in an entrepreneurial environment – and to help shape our plan to bring new products to patients.

    This individual will be responsible for providing leadership towards the creation of a robust FP&A function and will also support the development and maintenance of strategic plans for key business initiatives.

    Summary of Key Responsibilities:

    • Support the financial planning process, partnering with all functions / all levels to develop financial plans to execute against company priorities.
    • Create and maintain budgets, financial models, reporting and forecasts.
    • Prepare and analyze information for financial reporting and analysis including monthly results package for Dicerna’s financial performance reviews.
    • Improve performance across functions by identifying and assessing areas and trends where Dicerna can drive productivity and efficiency.
    • Support the continued development of budgeting, financial forecasting, operating plan and modeling tools.
    • Prepare financial reporting including variance and financial statement analysis, identify the business drivers behind financial data and identify potential implications on future results.
    • Support annual budget processes, incorporating business initiatives, economic trends and operational effectiveness.
    • Analyze complex financial information and reports to provide accurate and timely financial analysis to management.
    • Act as financial business partner for functional areas providing in-depth analysis and financial guidance, while identifying potential risks and opportunities.

    Required Skills & Qualifications:

    • Bachelor’s degree in accounting/finance, MBA preferred
    • Minimum of 7 to 10 years relevant industry experience, working knowledge of biotech product life cycles preferred.
    • Excellent interpersonal skills
    • Strong data analysis, technical and forecasting skills.
    • Strong understanding of financial systems, (Adaptive Planning or similar) and NPV modeling tools (Xplico or similar)
    • Outstanding organizational skills and ability to manage complexity and lead multiple projects simultaneously.
    • Ability to work independently and prioritize effectively and calm under pressure.
    • Adept at problem-solving and creative thinking– ability to provide pragmatic solutions and drive ideas to implementation.
    • Proven commitment to accuracy, integrity and confidentiality
    • Demonstrated customer service focus
    • Demonstrated track record of success working in a team-based environment

     

    Upload Résumé (We prefer PDF format)

  • Senior Intellectual Property Attorney

    Posted July 6, 2018

     

    We are seeking a Senior IP Attorney to become a key member of Dicerna’s team. The successful candidate will have responsibilities in many areas of IP practice, including IP strategy development, patent portfolio management, freedom-to-operate analyses, partnering activities (including diligence and IP generation), competitive intelligence, trade secrets, trademarks, and R&D agreements. This is a great opportunity to join a growing company in an important position and work on exciting technology in a fast-paced environment.

    Key Responsibilities

     Help design and execute Dicerna’s IP strategy.
     Manage Dicerna’s patent portfolio in collaboration with the SVP, Legal Affairs.
     Work closely with research & development scientists as well as clinical staff to ensure that emerging technology is protected and developed into assets of the company’s IP estate.
     Manage outside counsel in the drafting and prosecution of patent applications.
     Draft patent applications.
     Evaluate and monitor outside IP estates and maintain awareness of competitors’ positions; identify IP of potential value to the company.
     Prepare for IP due diligence in support of business development activities.
     Conduct FTO searches and analyses.
     Actively participate in collaborations with outside parties.
     Participate in disclosure review.
     Manage Dicerna trademarks.
     Help design and enact IP policies and procedures internally.
     Assist with contentious matters such as litigations, post-grant proceedings, etc.
     Contribute to the development and review of R&D agreements (CDAs, MSAs, etc.).
     Participate in the training and education of scientific staff on IP principles.

    Qualifications

     B.S./M.S. in a scientific discipline
     Minimum of 5 years related experience as a patent attorney in the pharmaceutical/biotechnology industry. Prefer law firm and in-house experience
     Ability to perform independently with sufficient flexibility to handle a wide range of legal issues
     Ability to multi-task and prioritize workload
     Strong business acumen and understanding of drug development
     Strong client service focus to build and sustain effective partnerships with key stakeholders and project teams within the company
     Excellent interpersonal skills and oral and written communication skills

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  • Supply Chain Manager

    Posted July 6, 2018

     

    We are seeking an experienced supply chain manager to join our manufacturing operations team.  The candidate will be responsible for developing and managing Dicerna’s supply of drug product through all stages of clinical development and commercial launch.

    Key Responsibilities

    • Responsible for all day-to-day activities related to managing the supply of starting materials, API, clinical and commercial drug product.
    • Coordinate and track domestic and international shipments across the supply chain.
    • Own clinical supply activities including planning, labeling, packaging and distribution of medicinal product for multiple programs.
    • Develop and implement overall supply plans based on CMC and clinical development plans.
    • Forecast supply needs in conjunction with clinical, program development and manufacturing.
    • Manage and monitor forecast activities related to drug substance, drug product and clinical supplies at the program and study level.
    • Negotiate and communicate supply plan timelines to internal and external partners.
    • Negotiate clinical and commercial supply agreements.
    • Ensure changes in supply configuration, trial design, enrollment timelines, manufacturing availability and regulatory requirements are implemented.
    • Work with finance and VP manufacturing to create clinical supply study budgets.
    • Work with internal regulatory, clinical, quality and CMC teams to ensure execution of all supply chain activities.

    Qualifications

    • BS degree in life sciences, chemistry or equivalent with 8+ years as a supply chain leader in the biopharmaceutical industry
    • Working knowledge of regulations related to clinical labeling, packaging and distribution activities globally (cGMP, GCP, ICH)
    • Strong project management skills
    • Experience managing relationships with CMOs/CROs

    Upload Résumé (We prefer PDF format)

  • Drug Product Manufacturing Manager

    Posted July 10, 2018

     

    Location: Boulder, CO Area

     

    Overview

    The successful candidate will be responsible for drug product manufacturing, and corresponding CMC regulatory activities.  This role requires thorough knowledge of cGMP for sterile pharmaceutical products.  This position will have significant cross functional interaction while supporting multiple projects. S/he will work closely with CMO’s and apply risk mitigation strategies to ensure the continuous supply of drug product.

     

    Key Responsibilities

    • Sterile Drug Product Manufacturing
    • Effectively manage ongoing projects and timelines
    • Provide risk assessment and supportive project planning
    • Support Investigations, corrective actions and CMC Regulatory submissions
    • Review of manufacturing records and analytical data as it pertains to the impact on the manufacturing process

     

     Qualifications

    • MS/BS in Biochemistry/Microbiology/Chemistry/Engineering or related discipline with 6 -10 years in a cGMP setting
    • In-depth experience in pharmaceutical engineering operations associated with aseptic processing
    • Experience working to standards required for national and international regulatory compliance of Aseptic Processing facilities
    • Understanding of engineering and process knowledge associated with various sterilization technologies, GMP utilities and associated pharmaceutical processes
    • Experience with the drug product formulation process
    • Understanding of equipment, instrumentation, and materials of construction to design, specify, procure, start-up, fully commission and troubleshoot equipment and systems
    • Ability to perform risk assessments
    • Proficiency in generating and executing protocols and report
    • Experience in problem solving and continuous improvement technique
    • Ability to work independently as well as part of a team
    • Strong planning & organizational skills with the ability to prioritize and work within deadlines

     

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  • Scientist II / Senior Scientist, RNAi Pharmacology

    Posted July 18, 2018

     

    Dicerna is seeking a highly-motivated, experienced scientist to join our innovative team.  The ideal candidate will have a background in employing rodent models to perform multi-dimensional evaluations of experimental molecular therapeutics (PK/PD/efficacy).  The candidate will be an integral part of our cross-functional R&D team, with a key role in expanding our discovery pipeline and enabling the success of strategic alliances with pharma partners.  The candidate will also contribute to IND/CTA filings and business development activities.

     

    Key Responsibilities

    • Project leadership: perform innovative and challenging science to meet milestones
    • Pharmacodynamic and pharmacokinetic characterization of novel experimental RNAi therapeutics in rodents, and generation of molecular endpoint data
    • Development or implementation of rodent disease/phenotypic models to achieve therapeutic proof-of-concept
    • Collaboration with discovery biologists and medicinal chemists for platform development and lead optimization; interface with external partners
    • Pharmacology support for nonclinical and clinical-stage pipeline programs
    • Generation and communication of study reports, data packages, SOPs and related documentation

     

    Qualifications

     Ph.D. (or MS+10) in Biology, Pharmacology, Biochemistry, Pharmaceutical Sciences or equivalent

    • Expertise in rodent pharmacology including study design, dosing, necropsy, tissue processing; strong molecular biology and assay development/implementation skills (examples, but not all necessarily required: qPCR, NGS, FACS, Western/ELISA, IHC/histology).  Working knowledge of drug discovery processes, SAR and PK/PD concepts
    • Commitment to scientific rigor, high data quality and careful documentation
    • Expertise in metabolic diseases, immunology, kidney or CNS biology is a plus, but a broad range of backgrounds will be considered.  Demonstrated scientific track record is required
    • Ability to interact effectively on multidisciplinary teams and participate in our exciting, dynamic company culture
    • Ability to multitask, prioritize and manage timelines, manage projects and/or people.
    • Strong scientific writing skills, and experience in delivering effective scientific presentations to internal or external teams
    • Experience or working knowledge in nucleic acid therapeutics is a plus

    Upload Résumé (We prefer PDF format)